Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1225c

Experiment: 7H9 with Ethionamide 0.1 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1223 and Rv1224 are separated by 1 nucleotidesRv1224 and Rv1225c are separated by 32 nucleotidesRv1225c and Rv1226c are separated by 110 nucleotides Rv1223: Rv1223 - Probable serine protease HtrA (DEGP protein), at 1,365,875 to 1,367,461 Rv1223 Rv1224: Rv1224 - Probable protein TatB, at 1,367,463 to 1,367,858 Rv1224 Rv1225c: Rv1225c - Conserved hypothetical protein, at 1,367,891 to 1,368,721 Rv1225c Rv1226c: Rv1226c - Probable transmembrane protein, at 1,368,832 to 1,370,295 Rv1226c Position (kb) 1367 1368 1369Strain fitness (log2 ratio) -2 -1 0 1at 1367.892 kb on + strandat 1368.192 kb on + strand, within Rv1225cat 1368.193 kb on - strand, within Rv1225cat 1368.193 kb on - strand, within Rv1225cat 1368.193 kb on - strand, within Rv1225cat 1368.238 kb on + strand, within Rv1225cat 1368.239 kb on - strand, within Rv1225cat 1368.239 kb on - strand, within Rv1225cat 1368.285 kb on + strand, within Rv1225cat 1368.285 kb on + strand, within Rv1225cat 1368.286 kb on - strand, within Rv1225cat 1368.286 kb on - strand, within Rv1225cat 1368.588 kb on + strand, within Rv1225cat 1368.588 kb on + strand, within Rv1225cat 1368.589 kb on - strand, within Rv1225cat 1368.726 kb on + strandat 1368.737 kb on + strandat 1368.738 kb on - strandat 1368.738 kb on - strandat 1368.930 kb on - strandat 1369.055 kb on - strand, within Rv1226cat 1369.487 kb on + strand, within Rv1226cat 1369.488 kb on - strand, within Rv1226cat 1369.528 kb on + strand, within Rv1226cat 1369.528 kb on + strand, within Rv1226cat 1369.528 kb on + strand, within Rv1226cat 1369.529 kb on - strand, within Rv1226c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ethionamide 0.1 ug/mL
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1,367,892 + +0.3
1,368,192 + Rv1225c 0.36 +0.1
1,368,193 - Rv1225c 0.36 -0.6
1,368,193 - Rv1225c 0.36 -1.7
1,368,193 - Rv1225c 0.36 -0.2
1,368,238 + Rv1225c 0.42 -1.7
1,368,239 - Rv1225c 0.42 -0.0
1,368,239 - Rv1225c 0.42 +0.3
1,368,285 + Rv1225c 0.47 -2.6
1,368,285 + Rv1225c 0.47 -0.2
1,368,286 - Rv1225c 0.48 -1.3
1,368,286 - Rv1225c 0.48 -1.2
1,368,588 + Rv1225c 0.84 -0.9
1,368,588 + Rv1225c 0.84 -0.2
1,368,589 - Rv1225c 0.84 -0.8
1,368,726 + -0.5
1,368,737 + -1.5
1,368,738 - -0.0
1,368,738 - +0.3
1,368,930 - +1.0
1,369,055 - Rv1226c 0.15 +1.5
1,369,487 + Rv1226c 0.45 +1.0
1,369,488 - Rv1226c 0.45 +0.2
1,369,528 + Rv1226c 0.48 -1.5
1,369,528 + Rv1226c 0.48 +0.5
1,369,528 + Rv1226c 0.48 -0.5
1,369,529 - Rv1226c 0.48 +0.3

Or see this region's nucleotide sequence