Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0533c

Experiment: 7H9 with Ethionamide 0.1 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0532 and Rv0533c overlap by 105 nucleotidesRv0533c and Rv0534c are separated by 81 nucleotidesRv0534c and Rv0535 are separated by 16 nucleotides Rv0532: Rv0532 - PE-PGRS family protein PE_PGRS6, at 622,793 to 624,577 Rv0532 Rv0533c: Rv0533c - 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III), at 624,473 to 625,480 Rv0533c Rv0534c: Rv0534c - 1,4-dihydroxy-2-naphthoate octaprenyltransferase MenA (DHNA-octaprenyltransferase), at 625,562 to 626,440 Rv0534c Rv0535: Rv0535 - Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase), at 626,457 to 627,251 Rv0535 Position (kb) 624 625 626Strain fitness (log2 ratio) -2 -1 0 1at 623.671 kb on + strand, within Rv0532at 623.672 kb on - strand, within Rv0532at 623.862 kb on - strand, within Rv0532at 623.862 kb on - strand, within Rv0532at 624.453 kb on + strandat 624.507 kb on + strandat 624.508 kb on - strandat 624.575 kb on + strandat 624.632 kb on - strand, within Rv0533cat 624.697 kb on + strand, within Rv0533cat 624.726 kb on - strand, within Rv0533cat 624.726 kb on - strand, within Rv0533cat 624.885 kb on - strand, within Rv0533cat 625.005 kb on + strand, within Rv0533cat 625.006 kb on - strand, within Rv0533cat 625.006 kb on - strand, within Rv0533cat 625.006 kb on - strand, within Rv0533cat 625.006 kb on - strand, within Rv0533cat 625.013 kb on + strand, within Rv0533cat 625.013 kb on + strand, within Rv0533cat 625.014 kb on - strand, within Rv0533cat 625.014 kb on - strand, within Rv0533cat 625.102 kb on - strand, within Rv0533cat 625.142 kb on + strand, within Rv0533cat 625.350 kb on + strand, within Rv0533cat 625.385 kb on + strandat 625.385 kb on + strandat 625.386 kb on - strandat 625.419 kb on + strandat 625.481 kb on - strandat 625.489 kb on + strandat 625.489 kb on + strandat 625.490 kb on - strandat 625.490 kb on - strandat 625.490 kb on - strandat 625.563 kb on + strandat 625.564 kb on - strandat 626.456 kb on + strandat 626.457 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ethionamide 0.1 ug/mL
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623,671 + Rv0532 0.49 +1.3
623,672 - Rv0532 0.49 -0.2
623,862 - Rv0532 0.60 -0.6
623,862 - Rv0532 0.60 -0.7
624,453 + -0.1
624,507 + -0.2
624,508 - -1.5
624,575 + -1.7
624,632 - Rv0533c 0.16 -0.6
624,697 + Rv0533c 0.22 -0.3
624,726 - Rv0533c 0.25 -0.3
624,726 - Rv0533c 0.25 -0.1
624,885 - Rv0533c 0.41 -0.1
625,005 + Rv0533c 0.53 -0.5
625,006 - Rv0533c 0.53 -1.8
625,006 - Rv0533c 0.53 -0.5
625,006 - Rv0533c 0.53 -0.6
625,006 - Rv0533c 0.53 -0.1
625,013 + Rv0533c 0.54 +1.1
625,013 + Rv0533c 0.54 +0.5
625,014 - Rv0533c 0.54 -0.9
625,014 - Rv0533c 0.54 -0.2
625,102 - Rv0533c 0.62 -0.3
625,142 + Rv0533c 0.66 -0.4
625,350 + Rv0533c 0.87 +0.3
625,385 + -0.7
625,385 + -0.4
625,386 - -0.3
625,419 + -1.1
625,481 - +0.7
625,489 + +0.1
625,489 + -0.0
625,490 - -0.9
625,490 - +0.3
625,490 - -0.7
625,563 + +1.0
625,564 - -0.2
626,456 + +0.3
626,457 - +0.8

Or see this region's nucleotide sequence