Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0436c

Experiment: 7H9 with Ethionamide 0.1 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0435c and Rv0436c overlap by 4 nucleotidesRv0436c and Rv0437c overlap by 4 nucleotidesRv0437c and Rv0438c are separated by 60 nucleotides Rv0435c: Rv0435c - Putative conserved ATPase, at 522,347 to 524,533 Rv0435c Rv0436c: Rv0436c - Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase), at 524,530 to 525,390 Rv0436c Rv0437c: Rv0437c - Possible phosphatidylserine decarboxylase Psd (PS decarboxylase), at 525,387 to 526,082 Rv0437c Rv0438c: Rv0438c - Probable molybdopterin biosynthesis protein MoeA2, at 526,143 to 527,360 Rv0438c Position (kb) 524 525 526Strain fitness (log2 ratio) -1 0 1 2 3at 523.817 kb on + strand, within Rv0435cat 523.817 kb on + strand, within Rv0435cat 523.817 kb on + strand, within Rv0435cat 523.820 kb on + strand, within Rv0435cat 524.115 kb on - strand, within Rv0435cat 524.247 kb on + strand, within Rv0435cat 524.248 kb on - strand, within Rv0435cat 524.932 kb on + strand, within Rv0436cat 524.932 kb on + strand, within Rv0436cat 524.933 kb on - strand, within Rv0436cat 525.032 kb on + strand, within Rv0436cat 525.116 kb on + strand, within Rv0436cat 525.347 kb on - strandat 525.359 kb on - strandat 525.359 kb on - strandat 525.470 kb on - strand, within Rv0437cat 525.506 kb on - strand, within Rv0437cat 526.093 kb on + strandat 526.093 kb on + strandat 526.093 kb on + strandat 526.094 kb on - strandat 526.145 kb on - strandat 526.297 kb on - strand, within Rv0438c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ethionamide 0.1 ug/mL
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523,817 + Rv0435c 0.67 -1.0
523,817 + Rv0435c 0.67 -0.6
523,817 + Rv0435c 0.67 -0.3
523,820 + Rv0435c 0.67 -0.5
524,115 - Rv0435c 0.81 +2.9
524,247 + Rv0435c 0.87 -0.0
524,248 - Rv0435c 0.87 -0.5
524,932 + Rv0436c 0.47 +0.8
524,932 + Rv0436c 0.47 +1.6
524,933 - Rv0436c 0.47 +1.1
525,032 + Rv0436c 0.58 +1.5
525,116 + Rv0436c 0.68 +2.3
525,347 - +1.7
525,359 - -0.5
525,359 - -0.3
525,470 - Rv0437c 0.12 -0.3
525,506 - Rv0437c 0.17 -1.6
526,093 + -1.3
526,093 + -1.1
526,093 + -0.5
526,094 - -0.3
526,145 - +1.3
526,297 - Rv0438c 0.13 -0.9

Or see this region's nucleotide sequence