Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0272c

Experiment: 7H9 with Ethionamide 0.1 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0271c and Rv0272c are separated by 113 nucleotidesRv0272c and Rv0273c overlap by 4 nucleotidesRv0273c and Rv0274 are separated by 96 nucleotides Rv0271c: Rv0271c - Probable acyl-CoA dehydrogenase FadE6, at 326,266 to 328,461 Rv0271c Rv0272c: Rv0272c - Unknown protein, at 328,575 to 329,708 Rv0272c Rv0273c: Rv0273c - Possible transcriptional regulatory protein, at 329,705 to 330,325 Rv0273c Rv0274: Rv0274 - Conserved protein, at 330,422 to 331,003 Rv0274 Position (kb) 328 329 330Strain fitness (log2 ratio) -2 -1 0 1 2 3at 327.755 kb on + strand, within Rv0271cat 327.755 kb on + strand, within Rv0271cat 327.755 kb on + strand, within Rv0271cat 327.756 kb on - strand, within Rv0271cat 327.964 kb on + strand, within Rv0271cat 327.965 kb on - strand, within Rv0271cat 327.965 kb on - strand, within Rv0271cat 328.000 kb on + strand, within Rv0271cat 328.099 kb on + strand, within Rv0271cat 328.100 kb on - strand, within Rv0271cat 328.249 kb on + strandat 328.433 kb on + strandat 328.434 kb on - strandat 328.449 kb on + strandat 328.450 kb on - strandat 328.648 kb on + strandat 328.703 kb on - strand, within Rv0272cat 328.970 kb on + strand, within Rv0272cat 329.239 kb on + strand, within Rv0272cat 329.240 kb on - strand, within Rv0272cat 329.285 kb on + strand, within Rv0272cat 329.515 kb on + strand, within Rv0272cat 329.551 kb on + strand, within Rv0272cat 329.602 kb on + strandat 329.602 kb on + strandat 329.603 kb on - strandat 329.731 kb on - strandat 329.807 kb on - strand, within Rv0273cat 330.036 kb on + strand, within Rv0273cat 330.175 kb on - strand, within Rv0273cat 330.180 kb on + strand, within Rv0273cat 330.180 kb on + strand, within Rv0273c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ethionamide 0.1 ug/mL
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327,755 + Rv0271c 0.68 -1.6
327,755 + Rv0271c 0.68 -0.6
327,755 + Rv0271c 0.68 -0.3
327,756 - Rv0271c 0.68 -0.5
327,964 + Rv0271c 0.77 +0.6
327,965 - Rv0271c 0.77 -0.7
327,965 - Rv0271c 0.77 -2.3
328,000 + Rv0271c 0.79 +0.5
328,099 + Rv0271c 0.83 -0.2
328,100 - Rv0271c 0.84 +0.0
328,249 + -0.4
328,433 + +1.0
328,434 - -0.9
328,449 + -0.5
328,450 - -1.0
328,648 + +1.1
328,703 - Rv0272c 0.11 -0.5
328,970 + Rv0272c 0.35 +0.2
329,239 + Rv0272c 0.59 -0.0
329,240 - Rv0272c 0.59 -1.2
329,285 + Rv0272c 0.63 +1.3
329,515 + Rv0272c 0.83 +2.9
329,551 + Rv0272c 0.86 +1.2
329,602 + -1.3
329,602 + -0.5
329,603 - +0.3
329,731 - +3.3
329,807 - Rv0273c 0.16 +0.3
330,036 + Rv0273c 0.53 -0.6
330,175 - Rv0273c 0.76 -1.2
330,180 + Rv0273c 0.76 +1.3
330,180 + Rv0273c 0.76 +0.8

Or see this region's nucleotide sequence