Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0037c

Experiment: 7H9 with Ethionamide 0.1 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0035 and Rv0036c are separated by 108 nucleotidesRv0036c and Rv0037c are separated by 47 nucleotidesRv0037c and Rv0038 are separated by 101 nucleotidesRv0038 and Rv0039c are separated by 91 nucleotides Rv0035: Rv0035 - Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase), at 37,259 to 38,947 Rv0035 Rv0036c: Rv0036c - Conserved protein, at 39,056 to 39,829 Rv0036c Rv0037c: Rv0037c - Probable conserved integral membrane protein, at 39,877 to 41,202 Rv0037c Rv0038: Rv0038 - Conserved protein, at 41,304 to 41,912 Rv0038 Rv0039c: Rv0039c - Possible conserved transmembrane protein, at 42,004 to 42,351 Rv0039c Position (kb) 39 40 41 42Strain fitness (log2 ratio) -2 -1 0 1 2at 39.290 kb on + strand, within Rv0036cat 39.291 kb on - strand, within Rv0036cat 39.291 kb on - strand, within Rv0036cat 39.291 kb on - strand, within Rv0036cat 39.343 kb on + strand, within Rv0036cat 39.344 kb on - strand, within Rv0036cat 39.845 kb on + strandat 39.874 kb on - strandat 39.878 kb on + strandat 39.937 kb on + strandat 39.938 kb on - strandat 39.941 kb on + strandat 39.967 kb on + strandat 40.025 kb on + strand, within Rv0037cat 40.025 kb on + strand, within Rv0037cat 40.025 kb on + strand, within Rv0037cat 40.025 kb on + strand, within Rv0037cat 40.026 kb on - strand, within Rv0037cat 40.026 kb on - strand, within Rv0037cat 40.026 kb on - strand, within Rv0037cat 40.026 kb on - strand, within Rv0037cat 40.026 kb on - strand, within Rv0037cat 40.026 kb on - strand, within Rv0037cat 40.026 kb on - strand, within Rv0037cat 40.026 kb on - strand, within Rv0037cat 40.026 kb on - strand, within Rv0037cat 40.026 kb on - strand, within Rv0037cat 40.142 kb on - strand, within Rv0037cat 40.156 kb on + strand, within Rv0037cat 40.156 kb on + strand, within Rv0037cat 40.156 kb on + strand, within Rv0037cat 40.157 kb on - strand, within Rv0037cat 40.157 kb on - strand, within Rv0037cat 40.238 kb on + strand, within Rv0037cat 40.238 kb on + strand, within Rv0037cat 40.239 kb on - strand, within Rv0037cat 40.474 kb on + strand, within Rv0037cat 40.474 kb on + strand, within Rv0037cat 40.475 kb on - strand, within Rv0037cat 40.475 kb on - strand, within Rv0037cat 40.496 kb on + strand, within Rv0037cat 40.543 kb on + strand, within Rv0037cat 40.544 kb on - strand, within Rv0037cat 40.849 kb on + strand, within Rv0037cat 41.180 kb on - strandat 41.248 kb on + strandat 41.374 kb on + strand, within Rv0038at 41.374 kb on + strand, within Rv0038at 41.374 kb on + strand, within Rv0038at 41.375 kb on - strand, within Rv0038at 41.427 kb on + strand, within Rv0038at 41.496 kb on + strand, within Rv0038at 41.497 kb on - strand, within Rv0038at 41.497 kb on - strand, within Rv0038at 41.633 kb on - strand, within Rv0038at 41.911 kb on - strandat 41.916 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ethionamide 0.1 ug/mL
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39,290 + Rv0036c 0.30 -0.3
39,291 - Rv0036c 0.30 +0.3
39,291 - Rv0036c 0.30 -0.0
39,291 - Rv0036c 0.30 +0.3
39,343 + Rv0036c 0.37 +0.1
39,344 - Rv0036c 0.37 -0.5
39,845 + -1.2
39,874 - -0.5
39,878 + +0.5
39,937 + -1.0
39,938 - +0.1
39,941 + +0.0
39,967 + -0.5
40,025 + Rv0037c 0.11 -2.2
40,025 + Rv0037c 0.11 -0.7
40,025 + Rv0037c 0.11 +1.3
40,025 + Rv0037c 0.11 +1.8
40,026 - Rv0037c 0.11 -0.6
40,026 - Rv0037c 0.11 -0.3
40,026 - Rv0037c 0.11 -1.2
40,026 - Rv0037c 0.11 -0.8
40,026 - Rv0037c 0.11 -1.1
40,026 - Rv0037c 0.11 +0.4
40,026 - Rv0037c 0.11 -0.9
40,026 - Rv0037c 0.11 +1.0
40,026 - Rv0037c 0.11 -0.2
40,026 - Rv0037c 0.11 -1.3
40,142 - Rv0037c 0.20 -1.1
40,156 + Rv0037c 0.21 -0.6
40,156 + Rv0037c 0.21 -0.5
40,156 + Rv0037c 0.21 -1.2
40,157 - Rv0037c 0.21 -1.0
40,157 - Rv0037c 0.21 -1.1
40,238 + Rv0037c 0.27 +0.8
40,238 + Rv0037c 0.27 +0.0
40,239 - Rv0037c 0.27 -1.0
40,474 + Rv0037c 0.45 -0.8
40,474 + Rv0037c 0.45 +0.0
40,475 - Rv0037c 0.45 -0.7
40,475 - Rv0037c 0.45 -1.0
40,496 + Rv0037c 0.47 -1.4
40,543 + Rv0037c 0.50 -1.1
40,544 - Rv0037c 0.50 -0.3
40,849 + Rv0037c 0.73 -1.1
41,180 - +0.6
41,248 + -0.5
41,374 + Rv0038 0.11 +1.0
41,374 + Rv0038 0.11 +0.3
41,374 + Rv0038 0.11 +1.7
41,375 - Rv0038 0.12 -0.1
41,427 + Rv0038 0.20 +1.3
41,496 + Rv0038 0.32 +0.2
41,497 - Rv0038 0.32 -0.2
41,497 - Rv0038 0.32 -0.7
41,633 - Rv0038 0.54 +0.0
41,911 - +1.3
41,916 - +0.8

Or see this region's nucleotide sequence