Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2041c

Experiment: 7H9 with Ethionamide 0.1 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2039c and Rv2040c overlap by 14 nucleotidesRv2040c and Rv2041c overlap by 4 nucleotidesRv2041c and Rv2042c are separated by 37 nucleotidesRv2042c and Rv2043c overlap by 1 nucleotides Rv2039c: Rv2039c - Probable sugar-transport integral membrane protein ABC transporter, at 2,284,799 to 2,285,641 Rv2039c Rv2040c: Rv2040c - Probable sugar-transport integral membrane protein ABC transporter, at 2,285,628 to 2,286,530 Rv2040c Rv2041c: Rv2041c - Probable sugar-binding lipoprotein, at 2,286,527 to 2,287,846 Rv2041c Rv2042c: Rv2042c - Conserved protein, at 2,287,884 to 2,288,681 Rv2042c Rv2043c: Rv2043c - Pyrazinamidase/nicotinamidase PncA (PZase), at 2,288,681 to 2,289,241 Rv2043c Position (kb) 2286 2287 2288Strain fitness (log2 ratio) -3 -2 -1 0 1 2at 2285.791 kb on + strand, within Rv2040cat 2285.796 kb on - strand, within Rv2040cat 2285.871 kb on + strand, within Rv2040cat 2285.969 kb on - strand, within Rv2040cat 2286.424 kb on + strand, within Rv2040cat 2286.425 kb on - strand, within Rv2040cat 2286.491 kb on + strandat 2286.491 kb on + strandat 2286.492 kb on - strandat 2286.711 kb on - strand, within Rv2041cat 2286.889 kb on + strand, within Rv2041cat 2287.095 kb on + strand, within Rv2041cat 2287.172 kb on + strand, within Rv2041cat 2287.173 kb on - strand, within Rv2041cat 2287.324 kb on + strand, within Rv2041cat 2287.410 kb on + strand, within Rv2041cat 2287.644 kb on - strand, within Rv2041cat 2287.874 kb on - strandat 2288.108 kb on - strand, within Rv2042cat 2288.233 kb on - strand, within Rv2042cat 2288.372 kb on - strand, within Rv2042cat 2288.376 kb on + strand, within Rv2042cat 2288.376 kb on + strand, within Rv2042cat 2288.846 kb on - strand, within Rv2043c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ethionamide 0.1 ug/mL
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2,285,791 + Rv2040c 0.18 +1.1
2,285,796 - Rv2040c 0.19 +1.1
2,285,871 + Rv2040c 0.27 +0.1
2,285,969 - Rv2040c 0.38 -0.5
2,286,424 + Rv2040c 0.88 -0.8
2,286,425 - Rv2040c 0.88 +1.7
2,286,491 + -3.0
2,286,491 + +1.1
2,286,492 - -0.0
2,286,711 - Rv2041c 0.14 +0.6
2,286,889 + Rv2041c 0.27 -0.6
2,287,095 + Rv2041c 0.43 +1.1
2,287,172 + Rv2041c 0.49 -1.8
2,287,173 - Rv2041c 0.49 -1.2
2,287,324 + Rv2041c 0.60 -0.5
2,287,410 + Rv2041c 0.67 -0.1
2,287,644 - Rv2041c 0.85 -1.5
2,287,874 - -1.0
2,288,108 - Rv2042c 0.28 +1.5
2,288,233 - Rv2042c 0.44 +0.1
2,288,372 - Rv2042c 0.61 +1.1
2,288,376 + Rv2042c 0.62 +0.7
2,288,376 + Rv2042c 0.62 +2.1
2,288,846 - Rv2043c 0.29 -1.2

Or see this region's nucleotide sequence