Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0545c

Experiment: 7H9 with Ethionamide 0.1 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0542c and Rv0543c are separated by 68 nucleotidesRv0543c and Rv0544c are separated by 59 nucleotidesRv0544c and Rv0545c overlap by 4 nucleotidesRv0545c and Rv0546c are separated by 119 nucleotidesRv0546c and Rv0547c are separated by 62 nucleotides Rv0542c: Rv0542c - Possible O-succinylbenzoic acid--CoA ligase MenE (OSB-CoA synthetase) (O-succinylbenzoate-CoA synthase), at 634,416 to 635,504 Rv0542c Rv0543c: Rv0543c - Conserved protein, at 635,573 to 635,875 Rv0543c Rv0544c: Rv0544c - Possible conserved transmembrane protein, at 635,935 to 636,213 Rv0544c Rv0545c: Rv0545c - Probable low-affinity inorganic phosphate transporter integral membrane protein PitA, at 636,210 to 637,463 Rv0545c Rv0546c: Rv0546c - Conserved protein, at 637,583 to 637,969 Rv0546c Rv0547c: Rv0547c - Possible oxidoreductase, at 638,032 to 638,916 Rv0547c Position (kb) 636 637 638Strain fitness (log2 ratio) -2 -1 0 1 2 3at 635.882 kb on - strandat 635.882 kb on - strandat 635.882 kb on - strandat 635.884 kb on - strandat 635.936 kb on + strandat 635.999 kb on + strand, within Rv0544cat 635.999 kb on + strand, within Rv0544cat 636.020 kb on - strand, within Rv0544cat 636.195 kb on - strandat 636.195 kb on - strandat 636.195 kb on - strandat 636.763 kb on + strand, within Rv0545cat 636.764 kb on - strand, within Rv0545cat 636.960 kb on - strand, within Rv0545cat 637.326 kb on + strand, within Rv0545cat 637.529 kb on - strandat 637.552 kb on - strandat 637.552 kb on - strandat 637.552 kb on - strandat 637.563 kb on - strandat 637.563 kb on - strandat 637.600 kb on + strandat 637.869 kb on + strand, within Rv0546cat 637.982 kb on - strandat 638.210 kb on + strand, within Rv0547cat 638.210 kb on + strand, within Rv0547cat 638.211 kb on - strand, within Rv0547cat 638.255 kb on + strand, within Rv0547cat 638.256 kb on - strand, within Rv0547cat 638.256 kb on - strand, within Rv0547cat 638.256 kb on - strand, within Rv0547cat 638.400 kb on + strand, within Rv0547cat 638.462 kb on + strand, within Rv0547cat 638.462 kb on + strand, within Rv0547cat 638.463 kb on - strand, within Rv0547cat 638.463 kb on - strand, within Rv0547c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ethionamide 0.1 ug/mL
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635,882 - +1.3
635,882 - -1.2
635,882 - -0.7
635,884 - -0.5
635,936 + -0.3
635,999 + Rv0544c 0.23 +1.7
635,999 + Rv0544c 0.23 +1.3
636,020 - Rv0544c 0.30 +0.4
636,195 - -0.1
636,195 - +1.3
636,195 - +0.7
636,763 + Rv0545c 0.44 +0.4
636,764 - Rv0545c 0.44 +0.7
636,960 - Rv0545c 0.60 +1.3
637,326 + Rv0545c 0.89 +0.4
637,529 - +1.1
637,552 - -0.4
637,552 - -0.0
637,552 - +0.3
637,563 - +2.1
637,563 - -0.6
637,600 + +0.8
637,869 + Rv0546c 0.74 -1.5
637,982 - -0.0
638,210 + Rv0547c 0.20 +1.7
638,210 + Rv0547c 0.20 -0.8
638,211 - Rv0547c 0.20 -0.7
638,255 + Rv0547c 0.25 -1.8
638,256 - Rv0547c 0.25 -0.0
638,256 - Rv0547c 0.25 -0.5
638,256 - Rv0547c 0.25 +0.8
638,400 + Rv0547c 0.42 -1.3
638,462 + Rv0547c 0.49 -0.1
638,462 + Rv0547c 0.49 +3.6
638,463 - Rv0547c 0.49 -0.7
638,463 - Rv0547c 0.49 -0.3

Or see this region's nucleotide sequence