Experiment: 7H9 with Ethionamide 0.1 ug/mL
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt Rv0184 and Rv0185 overlap by 4 nucleotides Rv0185 and Rv0186 are separated by 44 nucleotides Rv0186 and Rv0186A are separated by 45 nucleotides Rv0186A and Rv0187 are separated by 153 nucleotides
Rv0184: Rv0184 - Conserved hypothetical protein, at 214,969 to 215,718
Rv0184
Rv0185: Rv0185 - Conserved hypothetical protein, at 215,715 to 216,224
Rv0185
Rv0186: Rv0186 - Probable beta-glucosidase BglS (gentiobiase) (cellobiase) (beta-D-glucoside glucohydrolase), at 216,269 to 218,344
Rv0186
Rv0186A: Rv0186A - Metallothionein, MymT, at 218,390 to 218,551
Rv0186A
Rv0187: Rv0187 - Probable O-methyltransferase, at 218,705 to 219,367
Rv0187
Position (kb) 216
217
218
219 Strain fitness (log2 ratio) -2
-1
0
1
2 at 215.318 kb on + strand, within Rv0184 at 215.319 kb on - strand, within Rv0184 at 215.319 kb on - strand, within Rv0184 at 215.320 kb on + strand, within Rv0184 at 215.761 kb on - strand at 215.895 kb on + strand, within Rv0185 at 215.895 kb on + strand, within Rv0185 at 215.896 kb on - strand, within Rv0185 at 216.020 kb on + strand, within Rv0185 at 216.021 kb on - strand, within Rv0185 at 216.076 kb on + strand, within Rv0185 at 216.076 kb on + strand, within Rv0185 at 216.202 kb on - strand at 216.378 kb on - strand at 216.378 kb on - strand at 216.869 kb on + strand, within Rv0186 at 217.101 kb on + strand, within Rv0186 at 217.298 kb on - strand, within Rv0186 at 217.343 kb on + strand, within Rv0186 at 217.988 kb on + strand, within Rv0186 at 217.989 kb on - strand, within Rv0186 at 218.099 kb on + strand, within Rv0186 at 218.100 kb on - strand, within Rv0186 at 218.100 kb on - strand, within Rv0186 at 218.100 kb on - strand, within Rv0186 at 218.100 kb on - strand, within Rv0186 at 218.102 kb on - strand, within Rv0186 at 218.385 kb on + strand at 218.385 kb on + strand at 218.386 kb on - strand at 218.386 kb on - strand at 218.386 kb on - strand at 218.596 kb on + strand at 218.610 kb on + strand at 218.614 kb on + strand at 218.615 kb on - strand at 218.820 kb on + strand, within Rv0187 at 218.981 kb on + strand, within Rv0187 at 218.981 kb on + strand, within Rv0187 at 218.982 kb on - strand, within Rv0187 at 219.148 kb on + strand, within Rv0187 at 219.205 kb on + strand, within Rv0187 at 219.206 kb on - strand, within Rv0187 at 219.298 kb on - strand, within Rv0187
Per-strain Table
Position Strand Gene LocusTag Fraction 7H9 with Ethionamide 0.1 ug/mL remove 215,318 + Rv0184 0.47 -0.6 215,319 - Rv0184 0.47 -0.0 215,319 - Rv0184 0.47 -0.0 215,320 + Rv0184 0.47 -0.6 215,761 - -0.8 215,895 + Rv0185 0.35 -0.4 215,895 + Rv0185 0.35 +0.1 215,896 - Rv0185 0.35 -0.2 216,020 + Rv0185 0.60 -0.1 216,021 - Rv0185 0.60 +0.1 216,076 + Rv0185 0.71 -0.7 216,076 + Rv0185 0.71 -0.2 216,202 - +0.6 216,378 - -0.4 216,378 - -1.8 216,869 + Rv0186 0.29 -1.8 217,101 + Rv0186 0.40 +1.1 217,298 - Rv0186 0.50 -0.2 217,343 + Rv0186 0.52 -1.7 217,988 + Rv0186 0.83 +1.6 217,989 - Rv0186 0.83 -1.1 218,099 + Rv0186 0.88 -0.0 218,100 - Rv0186 0.88 -1.2 218,100 - Rv0186 0.88 -1.0 218,100 - Rv0186 0.88 -0.3 218,100 - Rv0186 0.88 +2.6 218,102 - Rv0186 0.88 -1.7 218,385 + +1.6 218,385 + +0.0 218,386 - +0.1 218,386 - -0.8 218,386 - +1.7 218,596 + -0.2 218,610 + -0.4 218,614 + -0.5 218,615 - +0.6 218,820 + Rv0187 0.17 -0.6 218,981 + Rv0187 0.42 +0.6 218,981 + Rv0187 0.42 +1.6 218,982 - Rv0187 0.42 +1.3 219,148 + Rv0187 0.67 +0.6 219,205 + Rv0187 0.75 +2.1 219,206 - Rv0187 0.76 -0.7 219,298 - Rv0187 0.89 +0.2
Or see this region's nucleotide sequence