Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3379c

Experiment: 7H9 with Isoniazid 0.025 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3377c and Rv3378c are separated by 4 nucleotidesRv3378c and Rv3379c are separated by 8 nucleotidesRv3379c and Rv3380c are separated by 232 nucleotides Rv3377c: Rv3377c - Halimadienyl diphosphate synthase, at 3,790,848 to 3,792,353 Rv3377c Rv3378c: Rv3378c - Diterpene synthase, at 3,792,358 to 3,793,248 Rv3378c Rv3379c: Rv3379c - Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs2 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS), at 3,793,257 to 3,794,867 Rv3379c Rv3380c: Rv3380c - Probable transposase, at 3,795,100 to 3,796,086 Rv3380c Position (kb) 3793 3794 3795Strain fitness (log2 ratio) -2 -1 0 1at 3792.289 kb on + strandat 3792.289 kb on + strandat 3792.289 kb on + strandat 3792.290 kb on - strandat 3792.331 kb on - strandat 3792.443 kb on - strandat 3792.548 kb on + strand, within Rv3378cat 3792.781 kb on + strand, within Rv3378cat 3793.186 kb on + strandat 3793.208 kb on - strandat 3793.336 kb on - strandat 3793.426 kb on + strand, within Rv3379cat 3793.427 kb on - strand, within Rv3379cat 3793.466 kb on + strand, within Rv3379cat 3793.503 kb on + strand, within Rv3379cat 3793.697 kb on + strand, within Rv3379cat 3793.818 kb on + strand, within Rv3379cat 3794.049 kb on + strand, within Rv3379cat 3794.291 kb on + strand, within Rv3379cat 3794.291 kb on + strand, within Rv3379cat 3794.292 kb on - strand, within Rv3379cat 3794.336 kb on + strand, within Rv3379cat 3794.336 kb on + strand, within Rv3379cat 3794.339 kb on + strand, within Rv3379cat 3794.339 kb on + strand, within Rv3379cat 3794.339 kb on + strand, within Rv3379cat 3794.388 kb on + strand, within Rv3379cat 3794.438 kb on - strand, within Rv3379cat 3794.441 kb on + strand, within Rv3379cat 3794.441 kb on + strand, within Rv3379cat 3794.533 kb on + strand, within Rv3379cat 3794.534 kb on - strand, within Rv3379cat 3794.918 kb on - strandat 3795.055 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Isoniazid 0.025 ug/mL
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3,792,289 + -0.3
3,792,289 + -0.9
3,792,289 + -1.7
3,792,290 - -2.2
3,792,331 - -2.5
3,792,443 - -0.6
3,792,548 + Rv3378c 0.21 -0.8
3,792,781 + Rv3378c 0.47 +0.9
3,793,186 + -1.6
3,793,208 - -0.0
3,793,336 - +0.0
3,793,426 + Rv3379c 0.10 -1.1
3,793,427 - Rv3379c 0.11 -0.8
3,793,466 + Rv3379c 0.13 -1.6
3,793,503 + Rv3379c 0.15 -1.1
3,793,697 + Rv3379c 0.27 -1.1
3,793,818 + Rv3379c 0.35 +0.3
3,794,049 + Rv3379c 0.49 +0.9
3,794,291 + Rv3379c 0.64 +1.2
3,794,291 + Rv3379c 0.64 +0.3
3,794,292 - Rv3379c 0.64 -1.2
3,794,336 + Rv3379c 0.67 -1.0
3,794,336 + Rv3379c 0.67 +1.6
3,794,339 + Rv3379c 0.67 +0.2
3,794,339 + Rv3379c 0.67 -1.1
3,794,339 + Rv3379c 0.67 +0.2
3,794,388 + Rv3379c 0.70 +0.8
3,794,438 - Rv3379c 0.73 -0.4
3,794,441 + Rv3379c 0.73 -0.1
3,794,441 + Rv3379c 0.73 -0.3
3,794,533 + Rv3379c 0.79 +0.3
3,794,534 - Rv3379c 0.79 -0.4
3,794,918 - +0.6
3,795,055 - -0.1

Or see this region's nucleotide sequence