Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3161c

Experiment: 7H9 with Isoniazid 0.025 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3159c and Rv3160c are separated by 174 nucleotidesRv3160c and Rv3161c are separated by 10 nucleotidesRv3161c and Rv3162c are separated by 69 nucleotidesRv3162c and Rv3163c overlap by 4 nucleotides Rv3159c: Rv3159c - PPE family protein PPE53, at 3,527,391 to 3,529,163 Rv3159c Rv3160c: Rv3160c - Possible transcriptional regulatory protein (probably TetR-family), at 3,529,338 to 3,529,979 Rv3160c Rv3161c: Rv3161c - Possible dioxygenase, at 3,529,990 to 3,531,138 Rv3161c Rv3162c: Rv3162c - Possible integral membrane protein, at 3,531,208 to 3,531,645 Rv3162c Rv3163c: Rv3163c - Possible conserved secreted protein, at 3,531,642 to 3,532,913 Rv3163c Position (kb) 3529 3530 3531 3532Strain fitness (log2 ratio) -3 -2 -1 0 1 2at 3529.234 kb on + strandat 3529.234 kb on + strandat 3529.234 kb on + strandat 3529.234 kb on + strandat 3529.235 kb on - strandat 3529.247 kb on - strandat 3529.340 kb on - strandat 3529.606 kb on - strand, within Rv3160cat 3529.838 kb on - strand, within Rv3160cat 3529.991 kb on + strandat 3529.991 kb on + strandat 3530.039 kb on + strandat 3530.073 kb on + strandat 3530.073 kb on + strandat 3530.499 kb on - strand, within Rv3161cat 3530.535 kb on + strand, within Rv3161cat 3530.726 kb on - strand, within Rv3161cat 3530.726 kb on - strand, within Rv3161cat 3530.936 kb on + strand, within Rv3161cat 3530.936 kb on + strand, within Rv3161cat 3530.937 kb on - strand, within Rv3161cat 3531.036 kb on - strandat 3531.056 kb on - strandat 3531.080 kb on + strandat 3531.081 kb on - strandat 3531.138 kb on + strandat 3531.239 kb on + strandat 3531.240 kb on - strandat 3531.240 kb on - strandat 3531.240 kb on - strandat 3531.396 kb on - strand, within Rv3162cat 3531.396 kb on - strand, within Rv3162cat 3531.621 kb on + strandat 3531.776 kb on - strand, within Rv3163cat 3531.845 kb on + strand, within Rv3163cat 3531.845 kb on + strand, within Rv3163c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Isoniazid 0.025 ug/mL
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3,529,234 + -1.2
3,529,234 + -0.6
3,529,234 + -0.1
3,529,234 + -0.5
3,529,235 - +1.3
3,529,247 - -0.6
3,529,340 - -0.5
3,529,606 - Rv3160c 0.42 +1.3
3,529,838 - Rv3160c 0.78 +1.5
3,529,991 + -0.2
3,529,991 + -1.5
3,530,039 + -0.3
3,530,073 + +0.3
3,530,073 + -1.0
3,530,499 - Rv3161c 0.44 -1.4
3,530,535 + Rv3161c 0.47 +1.1
3,530,726 - Rv3161c 0.64 +1.3
3,530,726 - Rv3161c 0.64 -0.3
3,530,936 + Rv3161c 0.82 +2.3
3,530,936 + Rv3161c 0.82 -0.2
3,530,937 - Rv3161c 0.82 +0.6
3,531,036 - +0.2
3,531,056 - -0.4
3,531,080 + -0.0
3,531,081 - +2.3
3,531,138 + +2.0
3,531,239 + -0.0
3,531,240 - -1.5
3,531,240 - -0.5
3,531,240 - -0.4
3,531,396 - Rv3162c 0.43 +0.1
3,531,396 - Rv3162c 0.43 +1.6
3,531,621 + -3.1
3,531,776 - Rv3163c 0.11 -0.5
3,531,845 + Rv3163c 0.16 +1.3
3,531,845 + Rv3163c 0.16 -0.5

Or see this region's nucleotide sequence