Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2184c

Experiment: 7H9 with Isoniazid 0.025 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2182c and Rv2183c are separated by 85 nucleotidesRv2183c and Rv2184c overlap by 4 nucleotidesRv2184c and Rv2185c are separated by 119 nucleotidesRv2185c and Rv2186c are separated by 104 nucleotides Rv2182c: Rv2182c - 1-acylglycerol-3-phosphate O-acyltransferase, at 2,444,586 to 2,445,329 Rv2182c Rv2183c: Rv2183c - Conserved protein, at 2,445,415 to 2,445,810 Rv2183c Rv2184c: Rv2184c - Conserved hypothetical protein, at 2,445,807 to 2,446,946 Rv2184c Rv2185c: Rv2185c - Conserved protein TB16.3, at 2,447,066 to 2,447,500 Rv2185c Rv2186c: Rv2186c - Conserved hypothetical protein, at 2,447,605 to 2,447,994 Rv2186c Position (kb) 2445 2446 2447Strain fitness (log2 ratio) -2 -1 0 1 2at 2445.373 kb on + strandat 2445.637 kb on + strand, within Rv2183cat 2445.849 kb on + strandat 2446.017 kb on + strand, within Rv2184cat 2446.055 kb on + strand, within Rv2184cat 2446.055 kb on + strand, within Rv2184cat 2446.055 kb on + strand, within Rv2184cat 2446.055 kb on + strand, within Rv2184cat 2446.279 kb on + strand, within Rv2184cat 2446.556 kb on - strand, within Rv2184cat 2446.939 kb on - strandat 2446.975 kb on - strandat 2447.109 kb on - strandat 2447.218 kb on - strand, within Rv2185cat 2447.238 kb on - strand, within Rv2185cat 2447.266 kb on + strand, within Rv2185cat 2447.378 kb on + strand, within Rv2185cat 2447.397 kb on + strand, within Rv2185cat 2447.506 kb on + strandat 2447.507 kb on - strandat 2447.507 kb on - strandat 2447.578 kb on + strandat 2447.579 kb on - strandat 2447.606 kb on + strandat 2447.607 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Isoniazid 0.025 ug/mL
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2,445,373 + -1.3
2,445,637 + Rv2183c 0.56 -0.1
2,445,849 + +1.2
2,446,017 + Rv2184c 0.18 +0.1
2,446,055 + Rv2184c 0.22 +0.8
2,446,055 + Rv2184c 0.22 +0.8
2,446,055 + Rv2184c 0.22 +0.5
2,446,055 + Rv2184c 0.22 +0.0
2,446,279 + Rv2184c 0.41 +0.6
2,446,556 - Rv2184c 0.66 -2.4
2,446,939 - +0.3
2,446,975 - -0.6
2,447,109 - -0.2
2,447,218 - Rv2185c 0.35 -0.6
2,447,238 - Rv2185c 0.40 +0.0
2,447,266 + Rv2185c 0.46 -0.7
2,447,378 + Rv2185c 0.72 +2.2
2,447,397 + Rv2185c 0.76 -0.3
2,447,506 + +0.2
2,447,507 - +0.5
2,447,507 - -1.5
2,447,578 + +0.5
2,447,579 - -0.6
2,447,606 + -0.3
2,447,607 - -1.8

Or see this region's nucleotide sequence