Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2029c

Experiment: 7H9 with Isoniazid 0.025 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2027c and Rv2028c are separated by 60 nucleotidesRv2028c and Rv2029c overlap by 4 nucleotidesRv2029c and Rv2030c are separated by 16 nucleotides Rv2027c: Rv2027c - Two component sensor histidine kinase DosT, at 2,272,787 to 2,274,508 Rv2027c Rv2028c: Rv2028c - Universal stress protein family protein, at 2,274,569 to 2,275,408 Rv2028c Rv2029c: Rv2029c - 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase), at 2,275,405 to 2,276,424 Rv2029c Rv2030c: Rv2030c - Conserved protein, at 2,276,441 to 2,278,486 Rv2030c Position (kb) 2275 2276 2277Strain fitness (log2 ratio) -3 -2 -1 0 1 2at 2274.510 kb on + strandat 2274.511 kb on - strandat 2274.511 kb on - strandat 2274.511 kb on - strandat 2274.511 kb on - strandat 2274.511 kb on - strandat 2274.514 kb on + strandat 2274.514 kb on + strandat 2274.514 kb on + strandat 2274.514 kb on + strandat 2274.515 kb on - strandat 2274.515 kb on - strandat 2274.515 kb on - strandat 2274.515 kb on - strandat 2274.515 kb on - strandat 2274.515 kb on - strandat 2274.515 kb on - strandat 2274.693 kb on - strand, within Rv2028cat 2274.718 kb on - strand, within Rv2028cat 2275.037 kb on - strand, within Rv2028cat 2275.370 kb on - strandat 2275.445 kb on + strandat 2275.446 kb on - strandat 2275.946 kb on + strand, within Rv2029cat 2275.947 kb on - strand, within Rv2029cat 2276.292 kb on - strand, within Rv2029cat 2276.443 kb on - strandat 2276.667 kb on - strand, within Rv2030cat 2276.918 kb on - strand, within Rv2030cat 2276.918 kb on - strand, within Rv2030cat 2277.057 kb on + strand, within Rv2030cat 2277.057 kb on + strand, within Rv2030cat 2277.058 kb on - strand, within Rv2030cat 2277.099 kb on + strand, within Rv2030cat 2277.099 kb on + strand, within Rv2030cat 2277.100 kb on - strand, within Rv2030cat 2277.231 kb on + strand, within Rv2030cat 2277.231 kb on + strand, within Rv2030cat 2277.231 kb on + strand, within Rv2030cat 2277.322 kb on - strand, within Rv2030cat 2277.372 kb on + strand, within Rv2030cat 2277.373 kb on - strand, within Rv2030c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Isoniazid 0.025 ug/mL
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2,274,510 + -1.5
2,274,511 - -0.7
2,274,511 - -2.6
2,274,511 - -0.1
2,274,511 - +0.4
2,274,511 - -0.6
2,274,514 + +0.0
2,274,514 + -1.4
2,274,514 + +0.0
2,274,514 + +1.5
2,274,515 - -0.7
2,274,515 - -0.3
2,274,515 - +0.1
2,274,515 - -1.7
2,274,515 - +0.0
2,274,515 - -3.1
2,274,515 - -0.1
2,274,693 - Rv2028c 0.15 +2.2
2,274,718 - Rv2028c 0.18 -0.3
2,275,037 - Rv2028c 0.56 -1.5
2,275,370 - -0.8
2,275,445 + -1.3
2,275,446 - -0.8
2,275,946 + Rv2029c 0.53 +0.6
2,275,947 - Rv2029c 0.53 -0.5
2,276,292 - Rv2029c 0.87 +0.4
2,276,443 - -0.3
2,276,667 - Rv2030c 0.11 -0.7
2,276,918 - Rv2030c 0.23 -0.1
2,276,918 - Rv2030c 0.23 -0.6
2,277,057 + Rv2030c 0.30 -0.0
2,277,057 + Rv2030c 0.30 +0.9
2,277,058 - Rv2030c 0.30 -1.7
2,277,099 + Rv2030c 0.32 +2.5
2,277,099 + Rv2030c 0.32 +0.2
2,277,100 - Rv2030c 0.32 -0.6
2,277,231 + Rv2030c 0.39 -0.4
2,277,231 + Rv2030c 0.39 -0.6
2,277,231 + Rv2030c 0.39 -0.2
2,277,322 - Rv2030c 0.43 -0.4
2,277,372 + Rv2030c 0.46 -0.6
2,277,373 - Rv2030c 0.46 +0.9

Or see this region's nucleotide sequence