Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0674

Experiment: 7H9 with Isoniazid 0.025 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0672 and Rv0673 are separated by 10 nucleotidesRv0673 and Rv0674 are separated by 2 nucleotidesRv0674 and Rv0675 overlap by 4 nucleotidesRv0675 and Rv0676c are separated by 11 nucleotides Rv0672: Rv0672 - Probable acyl-CoA dehydrogenase FadE8, at 771,484 to 773,112 Rv0672 Rv0673: Rv0673 - Possible enoyl-CoA hydratase EchA4 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase), at 773,123 to 774,061 Rv0673 Rv0674: Rv0674 - Conserved hypothetical protein, at 774,064 to 774,786 Rv0674 Rv0675: Rv0675 - Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase), at 774,783 to 775,574 Rv0675 Rv0676c: Rv0676c - Probable conserved transmembrane transport protein MmpL5, at 775,586 to 778,480 Rv0676c Position (kb) 774 775Strain fitness (log2 ratio) -1 0 1at 773.174 kb on + strandat 773.399 kb on + strand, within Rv0673at 773.415 kb on + strand, within Rv0673at 773.445 kb on + strand, within Rv0673at 773.446 kb on - strand, within Rv0673at 774.490 kb on - strand, within Rv0674at 775.492 kb on + strand, within Rv0675at 775.748 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Isoniazid 0.025 ug/mL
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773,174 + -0.2
773,399 + Rv0673 0.29 -0.7
773,415 + Rv0673 0.31 +0.7
773,445 + Rv0673 0.34 +0.3
773,446 - Rv0673 0.34 -0.1
774,490 - Rv0674 0.59 +0.8
775,492 + Rv0675 0.90 -0.3
775,748 - +0.1

Or see this region's nucleotide sequence