Experiment: 7H9 with Isoniazid 0.025 ug/mL
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt Rv0458 and Rv0459 overlap by 1 nucleotides Rv0459 and Rv0460 are separated by 59 nucleotides Rv0460 and Rv0461 are separated by 37 nucleotides Rv0461 and Rv0462 are separated by 63 nucleotides
Rv0458: Rv0458 - Probable aldehyde dehydrogenase, at 549,675 to 551,198
Rv0458
Rv0459: Rv0459 - Conserved hypothetical protein, at 551,198 to 551,689
Rv0459
Rv0460: Rv0460 - Conserved hydrophobic protein, at 551,749 to 551,988
Rv0460
Rv0461: Rv0461 - Probable transmembrane protein, at 552,026 to 552,550
Rv0461
Rv0462: Rv0462 - Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphorase), at 552,614 to 554,008
Rv0462
Position (kb) 552
553 Strain fitness (log2 ratio) -3
-2
-1
0
1
2 at 551.053 kb on - strand at 551.088 kb on + strand at 551.089 kb on - strand at 551.139 kb on + strand at 551.139 kb on + strand at 551.256 kb on + strand, within Rv0459 at 551.257 kb on - strand, within Rv0459 at 551.426 kb on + strand, within Rv0459 at 551.426 kb on + strand, within Rv0459 at 551.594 kb on + strand, within Rv0459 at 551.616 kb on + strand, within Rv0459 at 551.617 kb on - strand, within Rv0459 at 551.696 kb on + strand at 551.697 kb on - strand at 551.704 kb on + strand at 551.705 kb on - strand at 551.844 kb on - strand, within Rv0460 at 551.844 kb on - strand, within Rv0460 at 552.217 kb on - strand, within Rv0461 at 552.228 kb on - strand, within Rv0461 at 552.230 kb on - strand, within Rv0461 at 552.230 kb on - strand, within Rv0461 at 552.230 kb on - strand, within Rv0461 at 552.234 kb on - strand, within Rv0461 at 552.234 kb on - strand, within Rv0461 at 552.234 kb on - strand, within Rv0461 at 552.258 kb on + strand, within Rv0461 at 552.273 kb on + strand, within Rv0461 at 552.273 kb on + strand, within Rv0461 at 552.320 kb on + strand, within Rv0461 at 552.365 kb on + strand, within Rv0461 at 552.366 kb on - strand, within Rv0461 at 552.492 kb on - strand, within Rv0461 at 552.500 kb on + strand at 552.500 kb on + strand at 552.500 kb on + strand at 552.500 kb on + strand at 552.500 kb on + strand at 552.501 kb on - strand at 552.501 kb on - strand at 552.545 kb on + strand at 552.546 kb on - strand at 552.546 kb on - strand at 552.548 kb on + strand at 552.570 kb on + strand
Per-strain Table
Position Strand Gene LocusTag Fraction 7H9 with Isoniazid 0.025 ug/mL remove 551,053 - -1.1 551,088 + +0.5 551,089 - -2.0 551,139 + -0.2 551,139 + -0.4 551,256 + Rv0459 0.12 +0.3 551,257 - Rv0459 0.12 -1.7 551,426 + Rv0459 0.46 +0.1 551,426 + Rv0459 0.46 -1.6 551,594 + Rv0459 0.80 -0.1 551,616 + Rv0459 0.85 -1.4 551,617 - Rv0459 0.85 -1.6 551,696 + +1.3 551,697 - -1.6 551,704 + -0.3 551,705 - -0.6 551,844 - Rv0460 0.40 -0.8 551,844 - Rv0460 0.40 -0.1 552,217 - Rv0461 0.36 +1.3 552,228 - Rv0461 0.38 +0.8 552,230 - Rv0461 0.39 +0.3 552,230 - Rv0461 0.39 -0.8 552,230 - Rv0461 0.39 -0.8 552,234 - Rv0461 0.40 -2.1 552,234 - Rv0461 0.40 +0.1 552,234 - Rv0461 0.40 -0.3 552,258 + Rv0461 0.44 -2.1 552,273 + Rv0461 0.47 -1.2 552,273 + Rv0461 0.47 -3.0 552,320 + Rv0461 0.56 +0.1 552,365 + Rv0461 0.65 +0.3 552,366 - Rv0461 0.65 -1.2 552,492 - Rv0461 0.89 +2.3 552,500 + -1.3 552,500 + -0.3 552,500 + +0.4 552,500 + +0.7 552,500 + -0.6 552,501 - -0.0 552,501 - +0.4 552,545 + +0.7 552,546 - +0.2 552,546 - +0.5 552,548 + -0.6 552,570 + +0.2
Or see this region's nucleotide sequence