Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0262c

Experiment: 7H9 with Isoniazid 0.025 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0261c and Rv0262c are separated by 140 nucleotidesRv0262c and Rv0263c are separated by 9 nucleotidesRv0263c and Rv0264c are separated by 16 nucleotides Rv0261c: Rv0261c - Probable integral membrane nitrite extrusion protein NarK3 (nitrite facilitator), at 312,759 to 314,168 Rv0261c Rv0262c: Rv0262c - Aminoglycoside 2'-N-acetyltransferase Aac (Aac(2')-IC), at 314,309 to 314,854 Rv0262c Rv0263c: Rv0263c - Conserved hypothetical protein, at 314,864 to 315,766 Rv0263c Rv0264c: Rv0264c - Conserved hypothetical protein, at 315,783 to 316,415 Rv0264c Position (kb) 314 315Strain fitness (log2 ratio) -3 -2 -1 0 1 2at 313.451 kb on - strand, within Rv0261cat 313.541 kb on - strand, within Rv0261cat 313.582 kb on + strand, within Rv0261cat 313.583 kb on - strand, within Rv0261cat 313.585 kb on - strand, within Rv0261cat 313.585 kb on - strand, within Rv0261cat 313.918 kb on + strand, within Rv0261cat 314.169 kb on - strandat 314.179 kb on - strandat 314.310 kb on + strandat 314.478 kb on + strand, within Rv0262cat 314.523 kb on + strand, within Rv0262cat 314.617 kb on - strand, within Rv0262cat 314.617 kb on - strand, within Rv0262cat 314.643 kb on + strand, within Rv0262cat 314.880 kb on - strandat 314.997 kb on + strand, within Rv0263cat 315.117 kb on - strand, within Rv0263cat 315.178 kb on + strand, within Rv0263cat 315.178 kb on + strand, within Rv0263cat 315.424 kb on - strand, within Rv0263c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Isoniazid 0.025 ug/mL
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313,451 - Rv0261c 0.49 -0.5
313,541 - Rv0261c 0.55 -0.4
313,582 + Rv0261c 0.58 -0.6
313,583 - Rv0261c 0.58 -0.2
313,585 - Rv0261c 0.59 -0.8
313,585 - Rv0261c 0.59 +0.8
313,918 + Rv0261c 0.82 -1.7
314,169 - -0.2
314,179 - -2.3
314,310 + +1.1
314,478 + Rv0262c 0.31 -0.7
314,523 + Rv0262c 0.39 -0.3
314,617 - Rv0262c 0.56 -0.7
314,617 - Rv0262c 0.56 -0.7
314,643 + Rv0262c 0.61 -0.0
314,880 - -0.9
314,997 + Rv0263c 0.15 +2.3
315,117 - Rv0263c 0.28 +0.1
315,178 + Rv0263c 0.35 -0.1
315,178 + Rv0263c 0.35 +0.1
315,424 - Rv0263c 0.62 -3.6

Or see this region's nucleotide sequence