Experiment: 7H9 with Isoniazid 0.025 ug/mL
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt Rv0147 and Rv0148 are separated by 74 nucleotides Rv0148 and Rv0149 are separated by 6 nucleotides Rv0149 and Rv0150c overlap by 4 nucleotides
Rv0147: Rv0147 - Probable aldehyde dehydrogenase (NAD+) dependent, at 173,238 to 174,758
Rv0147
Rv0148: Rv0148 - Probable short-chain type dehydrogenase/reductase, at 174,833 to 175,693
Rv0148
Rv0149: Rv0149 - Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin), at 175,700 to 176,668
Rv0149
Rv0150c: Rv0150c - Conserved hypothetical protein, at 176,665 to 176,952
Rv0150c
Position (kb) 174
175
176 Strain fitness (log2 ratio) -2
-1
0
1
2
3 at 173.833 kb on - strand, within Rv0147 at 173.838 kb on + strand, within Rv0147 at 173.839 kb on - strand, within Rv0147 at 173.958 kb on + strand, within Rv0147 at 173.958 kb on + strand, within Rv0147 at 173.959 kb on - strand, within Rv0147 at 174.043 kb on + strand, within Rv0147 at 174.043 kb on + strand, within Rv0147 at 174.043 kb on + strand, within Rv0147 at 174.044 kb on - strand, within Rv0147 at 174.044 kb on - strand, within Rv0147 at 174.044 kb on - strand, within Rv0147 at 174.115 kb on - strand, within Rv0147 at 174.115 kb on - strand, within Rv0147 at 174.488 kb on + strand, within Rv0147 at 174.489 kb on - strand, within Rv0147 at 174.659 kb on + strand at 174.660 kb on - strand at 174.798 kb on + strand at 174.798 kb on + strand at 174.799 kb on - strand at 174.799 kb on - strand at 174.896 kb on + strand at 175.192 kb on + strand, within Rv0148 at 175.205 kb on + strand, within Rv0148 at 175.214 kb on + strand, within Rv0148 at 175.224 kb on + strand, within Rv0148 at 175.225 kb on - strand, within Rv0148 at 175.246 kb on - strand, within Rv0148 at 175.322 kb on + strand, within Rv0148 at 175.323 kb on - strand, within Rv0148 at 175.323 kb on - strand, within Rv0148 at 175.323 kb on - strand, within Rv0148 at 175.323 kb on - strand, within Rv0148 at 175.323 kb on - strand, within Rv0148 at 175.323 kb on - strand, within Rv0148 at 175.386 kb on - strand, within Rv0148 at 175.386 kb on - strand, within Rv0148 at 175.386 kb on - strand, within Rv0148 at 175.502 kb on + strand, within Rv0148 at 175.502 kb on + strand, within Rv0148 at 175.620 kb on + strand at 175.621 kb on - strand at 175.692 kb on - strand at 175.697 kb on + strand at 175.717 kb on - strand at 175.748 kb on + strand at 175.767 kb on + strand at 175.850 kb on + strand, within Rv0149 at 175.850 kb on + strand, within Rv0149 at 175.851 kb on - strand, within Rv0149 at 176.066 kb on + strand, within Rv0149 at 176.067 kb on - strand, within Rv0149 at 176.078 kb on + strand, within Rv0149 at 176.078 kb on + strand, within Rv0149 at 176.078 kb on + strand, within Rv0149 at 176.235 kb on - strand, within Rv0149 at 176.235 kb on - strand, within Rv0149 at 176.309 kb on + strand, within Rv0149 at 176.309 kb on + strand, within Rv0149 at 176.310 kb on - strand, within Rv0149 at 176.310 kb on - strand, within Rv0149 at 176.397 kb on + strand, within Rv0149 at 176.398 kb on - strand, within Rv0149 at 176.428 kb on - strand, within Rv0149 at 176.428 kb on - strand, within Rv0149 at 176.465 kb on - strand, within Rv0149 at 176.465 kb on - strand, within Rv0149 at 176.465 kb on - strand, within Rv0149 at 176.691 kb on + strand
Per-strain Table
Position Strand Gene LocusTag Fraction 7H9 with Isoniazid 0.025 ug/mL remove 173,833 - Rv0147 0.39 -0.9 173,838 + Rv0147 0.39 +0.9 173,839 - Rv0147 0.40 -0.4 173,958 + Rv0147 0.47 -0.1 173,958 + Rv0147 0.47 -0.8 173,959 - Rv0147 0.47 -0.6 174,043 + Rv0147 0.53 -0.8 174,043 + Rv0147 0.53 -0.7 174,043 + Rv0147 0.53 -2.6 174,044 - Rv0147 0.53 -0.4 174,044 - Rv0147 0.53 +0.2 174,044 - Rv0147 0.53 +0.6 174,115 - Rv0147 0.58 -1.6 174,115 - Rv0147 0.58 -2.4 174,488 + Rv0147 0.82 -0.4 174,489 - Rv0147 0.82 +2.3 174,659 + -0.5 174,660 - -1.0 174,798 + -1.4 174,798 + +0.0 174,799 - -0.7 174,799 - +0.0 174,896 + -1.2 175,192 + Rv0148 0.42 -0.8 175,205 + Rv0148 0.43 -1.0 175,214 + Rv0148 0.44 -0.1 175,224 + Rv0148 0.45 -1.4 175,225 - Rv0148 0.46 +1.0 175,246 - Rv0148 0.48 -1.3 175,322 + Rv0148 0.57 +0.3 175,323 - Rv0148 0.57 -1.7 175,323 - Rv0148 0.57 +1.4 175,323 - Rv0148 0.57 -0.8 175,323 - Rv0148 0.57 -1.3 175,323 - Rv0148 0.57 -0.6 175,323 - Rv0148 0.57 -2.2 175,386 - Rv0148 0.64 +1.5 175,386 - Rv0148 0.64 -1.1 175,386 - Rv0148 0.64 -2.5 175,502 + Rv0148 0.78 +0.3 175,502 + Rv0148 0.78 -0.3 175,620 + -0.7 175,621 - +0.2 175,692 - +0.9 175,697 + -0.5 175,717 - -1.0 175,748 + -0.4 175,767 + -1.0 175,850 + Rv0149 0.15 -0.1 175,850 + Rv0149 0.15 +0.0 175,851 - Rv0149 0.16 -0.1 176,066 + Rv0149 0.38 +2.3 176,067 - Rv0149 0.38 +3.3 176,078 + Rv0149 0.39 +1.7 176,078 + Rv0149 0.39 +0.0 176,078 + Rv0149 0.39 -0.5 176,235 - Rv0149 0.55 -0.7 176,235 - Rv0149 0.55 +0.7 176,309 + Rv0149 0.63 -0.9 176,309 + Rv0149 0.63 +0.6 176,310 - Rv0149 0.63 +0.3 176,310 - Rv0149 0.63 -1.1 176,397 + Rv0149 0.72 +1.3 176,398 - Rv0149 0.72 -0.4 176,428 - Rv0149 0.75 +0.3 176,428 - Rv0149 0.75 -2.1 176,465 - Rv0149 0.79 +0.5 176,465 - Rv0149 0.79 -1.6 176,465 - Rv0149 0.79 -0.2 176,691 + -1.0
Or see this region's nucleotide sequence