Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3420c

Experiment: 7H9 with Isoniazid 0.025 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3419c and Rv3420c overlap by 4 nucleotidesRv3420c and Rv3421c overlap by 4 nucleotidesRv3421c and Rv3422c overlap by 4 nucleotides Rv3419c: Rv3419c - Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease), at 3,837,555 to 3,838,589 Rv3419c Rv3420c: Rv3420c - Ribosomal-protein-alanine acetyltransferase RimI (acetylating enzyme for N-terminal of ribosomal protein S18), at 3,838,586 to 3,839,062 Rv3420c Rv3421c: Rv3421c - Conserved hypothetical protein, at 3,839,059 to 3,839,694 Rv3421c Rv3422c: Rv3422c - Conserved hypothetical protein, at 3,839,691 to 3,840,197 Rv3422c Position (kb) 3838 3839 3840Strain fitness (log2 ratio) -2 -1 0 1at 3837.955 kb on + strand, within Rv3419cat 3838.167 kb on - strand, within Rv3419cat 3838.167 kb on - strand, within Rv3419cat 3838.220 kb on - strand, within Rv3419cat 3838.621 kb on - strandat 3838.800 kb on + strand, within Rv3420cat 3838.911 kb on + strand, within Rv3420cat 3838.912 kb on - strand, within Rv3420cat 3838.912 kb on - strand, within Rv3420cat 3839.102 kb on + strandat 3839.103 kb on - strandat 3839.103 kb on - strandat 3839.400 kb on - strand, within Rv3421cat 3839.678 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Isoniazid 0.025 ug/mL
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3,837,955 + Rv3419c 0.39 -1.2
3,838,167 - Rv3419c 0.59 -0.0
3,838,167 - Rv3419c 0.59 -2.0
3,838,220 - Rv3419c 0.64 +0.8
3,838,621 - -1.2
3,838,800 + Rv3420c 0.45 -1.1
3,838,911 + Rv3420c 0.68 -0.3
3,838,912 - Rv3420c 0.68 -0.4
3,838,912 - Rv3420c 0.68 +0.1
3,839,102 + +1.2
3,839,103 - -1.1
3,839,103 - -1.2
3,839,400 - Rv3421c 0.54 -0.8
3,839,678 - -1.5

Or see this region's nucleotide sequence