Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2780

Experiment: 7H9 with Isoniazid 0.025 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2778c and Rv2779c are separated by 31 nucleotidesRv2779c and Rv2780 are separated by 65 nucleotidesRv2780 and Rv2781c are separated by 14 nucleotides Rv2778c: Rv2778c - Conserved protein, at 3,085,713 to 3,086,183 Rv2778c Rv2779c: Rv2779c - Possible transcriptional regulatory protein (probably Lrp/AsnC-family), at 3,086,215 to 3,086,754 Rv2779c Rv2780: Rv2780 - Secreted L-alanine dehydrogenase Ald (40 kDa antigen) (TB43), at 3,086,820 to 3,087,935 Rv2780 Rv2781c: Rv2781c - Possible alanine rich oxidoreductase, at 3,087,950 to 3,088,984 Rv2781c Position (kb) 3086 3087 3088Strain fitness (log2 ratio) -2 -1 0 1 2 3at 3085.891 kb on + strand, within Rv2778cat 3085.892 kb on - strand, within Rv2778cat 3085.913 kb on + strand, within Rv2778cat 3085.914 kb on - strand, within Rv2778cat 3085.914 kb on - strand, within Rv2778cat 3085.926 kb on + strand, within Rv2778cat 3085.927 kb on - strand, within Rv2778cat 3085.927 kb on - strand, within Rv2778cat 3085.927 kb on - strand, within Rv2778cat 3086.118 kb on + strand, within Rv2778cat 3086.118 kb on + strand, within Rv2778cat 3086.195 kb on - strandat 3086.217 kb on - strandat 3086.217 kb on - strandat 3086.266 kb on - strandat 3086.376 kb on - strand, within Rv2779cat 3086.376 kb on - strand, within Rv2779cat 3086.376 kb on - strand, within Rv2779cat 3086.511 kb on - strand, within Rv2779cat 3086.593 kb on + strand, within Rv2779cat 3086.750 kb on - strandat 3086.798 kb on + strandat 3086.897 kb on - strandat 3087.029 kb on - strand, within Rv2780at 3087.168 kb on + strand, within Rv2780at 3087.200 kb on - strand, within Rv2780at 3087.258 kb on + strand, within Rv2780at 3087.258 kb on + strand, within Rv2780at 3087.620 kb on - strand, within Rv2780at 3087.667 kb on - strand, within Rv2780at 3087.751 kb on - strand, within Rv2780at 3088.173 kb on + strand, within Rv2781cat 3088.174 kb on - strand, within Rv2781cat 3088.521 kb on + strand, within Rv2781cat 3088.675 kb on - strand, within Rv2781cat 3088.701 kb on + strand, within Rv2781cat 3088.702 kb on - strand, within Rv2781cat 3088.704 kb on + strand, within Rv2781cat 3088.705 kb on - strand, within Rv2781cat 3088.735 kb on - strand, within Rv2781cat 3088.857 kb on + strand, within Rv2781c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Isoniazid 0.025 ug/mL
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3,085,891 + Rv2778c 0.38 -1.0
3,085,892 - Rv2778c 0.38 +0.5
3,085,913 + Rv2778c 0.42 +0.3
3,085,914 - Rv2778c 0.43 +0.0
3,085,914 - Rv2778c 0.43 +2.0
3,085,926 + Rv2778c 0.45 +1.8
3,085,927 - Rv2778c 0.45 -0.4
3,085,927 - Rv2778c 0.45 -0.2
3,085,927 - Rv2778c 0.45 +3.4
3,086,118 + Rv2778c 0.86 +2.8
3,086,118 + Rv2778c 0.86 -1.0
3,086,195 - -0.5
3,086,217 - -0.0
3,086,217 - -1.1
3,086,266 - -0.9
3,086,376 - Rv2779c 0.30 -1.2
3,086,376 - Rv2779c 0.30 -0.7
3,086,376 - Rv2779c 0.30 -0.3
3,086,511 - Rv2779c 0.55 +2.8
3,086,593 + Rv2779c 0.70 -0.8
3,086,750 - -1.8
3,086,798 + -0.4
3,086,897 - -2.1
3,087,029 - Rv2780 0.19 -2.3
3,087,168 + Rv2780 0.31 -0.9
3,087,200 - Rv2780 0.34 -0.2
3,087,258 + Rv2780 0.39 -0.4
3,087,258 + Rv2780 0.39 +0.4
3,087,620 - Rv2780 0.72 +1.7
3,087,667 - Rv2780 0.76 -0.4
3,087,751 - Rv2780 0.83 +0.7
3,088,173 + Rv2781c 0.22 -0.7
3,088,174 - Rv2781c 0.22 -0.4
3,088,521 + Rv2781c 0.55 -0.4
3,088,675 - Rv2781c 0.70 -0.6
3,088,701 + Rv2781c 0.73 -1.1
3,088,702 - Rv2781c 0.73 -0.9
3,088,704 + Rv2781c 0.73 -0.4
3,088,705 - Rv2781c 0.73 -0.5
3,088,735 - Rv2781c 0.76 -0.3
3,088,857 + Rv2781c 0.88 -0.1

Or see this region's nucleotide sequence