Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2403c

Experiment: 7H9 with Isoniazid 0.025 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2402 and Rv2403c are separated by 77 nucleotidesRv2403c and Rv2404c overlap by 4 nucleotides Rv2402: Rv2402 - Conserved protein, at 2,698,529 to 2,700,457 Rv2402 Rv2403c: Rv2403c - Probable conserved lipoprotein LppR, at 2,700,535 to 2,701,290 Rv2403c Rv2404c: Rv2404c - Probable GTP-binding protein LepA (GTP-binding elongation factor), at 2,701,287 to 2,703,248 Rv2404c Position (kb) 2700 2701 2702Strain fitness (log2 ratio) -2 -1 0 1 2 3at 2699.558 kb on + strand, within Rv2402at 2699.616 kb on - strand, within Rv2402at 2699.654 kb on + strand, within Rv2402at 2699.655 kb on - strand, within Rv2402at 2699.655 kb on - strand, within Rv2402at 2699.703 kb on - strand, within Rv2402at 2699.742 kb on + strand, within Rv2402at 2699.743 kb on - strand, within Rv2402at 2699.743 kb on - strand, within Rv2402at 2700.006 kb on - strand, within Rv2402at 2700.140 kb on + strand, within Rv2402at 2700.214 kb on - strand, within Rv2402at 2700.455 kb on + strandat 2700.455 kb on + strandat 2700.709 kb on + strand, within Rv2403cat 2701.439 kb on - strandat 2701.585 kb on + strand, within Rv2404cat 2701.585 kb on + strand, within Rv2404cat 2701.586 kb on - strand, within Rv2404cat 2701.706 kb on - strand, within Rv2404cat 2701.771 kb on + strand, within Rv2404cat 2701.801 kb on + strand, within Rv2404cat 2701.801 kb on + strand, within Rv2404cat 2701.802 kb on - strand, within Rv2404cat 2701.802 kb on - strand, within Rv2404cat 2701.802 kb on - strand, within Rv2404cat 2701.984 kb on + strand, within Rv2404cat 2702.122 kb on + strand, within Rv2404cat 2702.122 kb on + strand, within Rv2404cat 2702.122 kb on + strand, within Rv2404c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Isoniazid 0.025 ug/mL
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2,699,558 + Rv2402 0.53 -0.5
2,699,616 - Rv2402 0.56 +0.7
2,699,654 + Rv2402 0.58 -2.0
2,699,655 - Rv2402 0.58 -2.4
2,699,655 - Rv2402 0.58 -0.4
2,699,703 - Rv2402 0.61 -0.4
2,699,742 + Rv2402 0.63 -0.8
2,699,743 - Rv2402 0.63 -1.1
2,699,743 - Rv2402 0.63 +0.2
2,700,006 - Rv2402 0.77 +1.6
2,700,140 + Rv2402 0.84 +0.0
2,700,214 - Rv2402 0.87 +1.8
2,700,455 + -0.8
2,700,455 + +0.2
2,700,709 + Rv2403c 0.23 +0.1
2,701,439 - +2.2
2,701,585 + Rv2404c 0.15 +3.2
2,701,585 + Rv2404c 0.15 +2.6
2,701,586 - Rv2404c 0.15 +3.2
2,701,706 - Rv2404c 0.21 +2.2
2,701,771 + Rv2404c 0.25 +2.5
2,701,801 + Rv2404c 0.26 +1.0
2,701,801 + Rv2404c 0.26 +2.7
2,701,802 - Rv2404c 0.26 +2.7
2,701,802 - Rv2404c 0.26 +3.4
2,701,802 - Rv2404c 0.26 +2.2
2,701,984 + Rv2404c 0.36 +2.9
2,702,122 + Rv2404c 0.43 +2.2
2,702,122 + Rv2404c 0.43 +1.7
2,702,122 + Rv2404c 0.43 +2.1

Or see this region's nucleotide sequence