Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2181

Experiment: 7H9 with Isoniazid 0.025 ug/mL

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

Per-strain Table

Position	Strand	Gene	LocusTag	Fraction	7H9 with Isoniazid 0.025 ug/mL
2,442,460	+		Rv2180c	0.15	+0.1
2,442,460	+		Rv2180c	0.15	-0.3
2,442,460	+		Rv2180c	0.15	-0.6
2,442,460	+		Rv2180c	0.15	-1.0
2,442,461	-		Rv2180c	0.15	+0.2
2,442,461	-		Rv2180c	0.15	-0.1
2,442,550	+		Rv2180c	0.25	-0.9
2,442,551	-		Rv2180c	0.25	+0.8
2,442,551	-		Rv2180c	0.25	+0.8
2,442,771	+		Rv2180c	0.50	+0.1
2,442,772	-		Rv2180c	0.50	-0.2
2,442,851	-		Rv2180c	0.59	+2.8
2,442,880	+		Rv2180c	0.62	+0.2
2,442,880	+		Rv2180c	0.62	+1.8
2,443,221	-				-0.1
2,443,239	+				-0.1
2,443,239	+				-0.4
2,443,239	+				+0.1
2,443,239	+				-0.8
2,443,239	+				+0.8
2,443,240	-				+1.0
2,443,283	+				+0.4
2,443,284	-				-0.8
2,443,286	+				+0.2
2,443,287	-				-0.3
2,443,395	+				-1.0
2,443,395	+				-1.3
2,443,450	-		Rv2181	0.12	-1.4
2,443,491	+		Rv2181	0.15	-0.4
2,443,545	+		Rv2181	0.19	-1.5
2,443,545	+		Rv2181	0.19	-1.6
2,443,545	+		Rv2181	0.19	-1.9
2,443,546	-		Rv2181	0.19	-0.4
2,443,624	+		Rv2181	0.25	-0.3
2,443,625	-		Rv2181	0.25	-0.7
2,444,032	-		Rv2181	0.57	-1.2
2,444,042	+		Rv2181	0.58	-0.8
2,444,043	-		Rv2181	0.58	-0.4
2,444,189	-		Rv2181	0.69	-1.2
2,444,189	-		Rv2181	0.69	-1.1
2,444,263	+		Rv2181	0.75	-0.4
2,444,263	+		Rv2181	0.75	-0.6
2,444,264	-		Rv2181	0.75	-1.8
2,444,264	-		Rv2181	0.75	-0.9
2,444,329	+		Rv2181	0.80	-0.2
2,444,472	+				-1.0
2,444,472	+				-1.4
2,444,473	-				+0.5
2,444,587	+				+0.4
2,445,373	+				-0.7