Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1833c

Experiment: 7H9 with Isoniazid 0.025 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1832 and Rv1833c are separated by 226 nucleotidesRv1833c and Rv1834 are separated by 40 nucleotidesRv1834 and Rv1835c are separated by 4 nucleotides Rv1832: Rv1832 - Probable glycine dehydrogenase GcvB (glycine decarboxylase) (glycine cleavage system P-protein), at 2,075,877 to 2,078,702 Rv1832 Rv1833c: Rv1833c - Possible haloalkane dehalogenase, at 2,078,929 to 2,079,789 Rv1833c Rv1834: Rv1834 - Probable hydrolase, at 2,079,830 to 2,080,696 Rv1834 Rv1835c: Rv1835c - Conserved hypothetical protein, at 2,080,701 to 2,082,587 Rv1835c Position (kb) 2078 2079 2080Strain fitness (log2 ratio) -2 -1 0 1 2 3at 2078.687 kb on - strandat 2078.746 kb on + strandat 2078.747 kb on - strandat 2078.758 kb on - strandat 2078.865 kb on + strandat 2078.866 kb on - strandat 2079.191 kb on - strand, within Rv1833cat 2079.250 kb on - strand, within Rv1833cat 2079.641 kb on + strand, within Rv1833cat 2079.642 kb on - strand, within Rv1833cat 2079.790 kb on + strandat 2080.281 kb on + strand, within Rv1834at 2080.282 kb on - strand, within Rv1834at 2080.282 kb on - strand, within Rv1834at 2080.457 kb on + strand, within Rv1834at 2080.458 kb on - strand, within Rv1834at 2080.458 kb on - strand, within Rv1834at 2080.661 kb on + strandat 2080.662 kb on - strandat 2080.710 kb on + strandat 2080.710 kb on + strandat 2080.711 kb on - strandat 2080.711 kb on - strandat 2080.753 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Isoniazid 0.025 ug/mL
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2,078,687 - -1.8
2,078,746 + -0.5
2,078,747 - +0.1
2,078,758 - -0.3
2,078,865 + -0.5
2,078,866 - +2.4
2,079,191 - Rv1833c 0.30 -0.2
2,079,250 - Rv1833c 0.37 -0.1
2,079,641 + Rv1833c 0.83 -0.2
2,079,642 - Rv1833c 0.83 -0.2
2,079,790 + -0.1
2,080,281 + Rv1834 0.52 -0.8
2,080,282 - Rv1834 0.52 -0.9
2,080,282 - Rv1834 0.52 -0.1
2,080,457 + Rv1834 0.72 -0.0
2,080,458 - Rv1834 0.72 +2.8
2,080,458 - Rv1834 0.72 -2.6
2,080,661 + -0.5
2,080,662 - +0.8
2,080,710 + -0.8
2,080,710 + -0.5
2,080,711 - -0.4
2,080,711 - -0.2
2,080,753 + -1.5

Or see this region's nucleotide sequence