Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1022

Experiment: 7H9 with Isoniazid 0.025 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1021 and Rv1022 are separated by 87 nucleotidesRv1022 and Rv1023 are separated by 96 nucleotides Rv1021: Rv1021 - Conserved protein, at 1,142,671 to 1,143,648 Rv1021 Rv1022: Rv1022 - Probable conserved lipoprotein LpqU, at 1,143,736 to 1,144,467 Rv1022 Rv1023: Rv1023 - Probable enolase Eno, at 1,144,564 to 1,145,853 Rv1023 Position (kb) 1143 1144 1145Strain fitness (log2 ratio) -3 -2 -1 0 1at 1142.752 kb on + strandat 1142.869 kb on - strand, within Rv1021at 1143.032 kb on - strand, within Rv1021at 1143.711 kb on + strandat 1143.713 kb on + strandat 1143.973 kb on + strand, within Rv1022at 1144.109 kb on + strand, within Rv1022at 1144.110 kb on - strand, within Rv1022at 1144.331 kb on - strand, within Rv1022at 1144.334 kb on + strand, within Rv1022at 1144.334 kb on + strand, within Rv1022at 1144.407 kb on + strandat 1144.411 kb on + strandat 1144.466 kb on - strandat 1144.466 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Isoniazid 0.025 ug/mL
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1,142,752 + +0.4
1,142,869 - Rv1021 0.20 -0.8
1,143,032 - Rv1021 0.37 +0.5
1,143,711 + +0.2
1,143,713 + +0.7
1,143,973 + Rv1022 0.32 -0.7
1,144,109 + Rv1022 0.51 -1.2
1,144,110 - Rv1022 0.51 +0.0
1,144,331 - Rv1022 0.81 -0.7
1,144,334 + Rv1022 0.82 +0.2
1,144,334 + Rv1022 0.82 -1.4
1,144,407 + -1.7
1,144,411 + +1.2
1,144,466 - +0.2
1,144,466 - -3.0

Or see this region's nucleotide sequence