Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0980c

Experiment: 7H9 with Isoniazid 0.025 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0978c and Rv0979c are separated by 313 nucleotidesRv0979c and Rv0979A are separated by 21 nucleotidesRv0979A and Rv0980c are separated by 18 nucleotidesRv0980c and Rv0981 are separated by 370 nucleotides Rv0978c: Rv0978c - PE-PGRS family protein PE_PGRS17, at 1,093,361 to 1,094,356 Rv0978c Rv0979c: Rv0979c - Hypothetical protein, at 1,094,670 to 1,094,864 Rv0979c Rv0979A: Rv0979A - 50S ribosomal protein L32 RpmF, at 1,094,886 to 1,095,059 Rv0979A Rv0980c: Rv0980c - PE-PGRS family protein PE_PGRS18, at 1,095,078 to 1,096,451 Rv0980c Rv0981: Rv0981 - Mycobacterial persistence regulator MRPA (two component response transcriptional regulatory protein), at 1,096,822 to 1,097,508 Rv0981 Position (kb) 1095 1096 1097Strain fitness (log2 ratio) -2 -1 0 1 2 3at 1094.576 kb on + strandat 1094.576 kb on + strandat 1094.577 kb on - strandat 1095.081 kb on + strandat 1095.082 kb on - strandat 1095.082 kb on - strandat 1095.149 kb on + strandat 1095.149 kb on + strandat 1095.286 kb on + strand, within Rv0980cat 1095.286 kb on + strand, within Rv0980cat 1095.286 kb on + strand, within Rv0980cat 1095.287 kb on - strand, within Rv0980cat 1095.287 kb on - strand, within Rv0980cat 1095.287 kb on - strand, within Rv0980cat 1095.287 kb on - strand, within Rv0980cat 1095.287 kb on - strand, within Rv0980cat 1095.287 kb on - strand, within Rv0980cat 1095.287 kb on - strand, within Rv0980cat 1095.536 kb on - strand, within Rv0980cat 1095.536 kb on - strand, within Rv0980cat 1095.536 kb on - strand, within Rv0980cat 1095.536 kb on - strand, within Rv0980cat 1096.205 kb on + strand, within Rv0980cat 1096.205 kb on + strand, within Rv0980cat 1096.205 kb on + strand, within Rv0980cat 1096.768 kb on + strandat 1096.769 kb on - strandat 1096.769 kb on - strandat 1097.114 kb on - strand, within Rv0981at 1097.118 kb on - strand, within Rv0981at 1097.118 kb on - strand, within Rv0981at 1097.364 kb on - strand, within Rv0981at 1097.364 kb on - strand, within Rv0981at 1097.416 kb on + strand, within Rv0981at 1097.417 kb on - strand, within Rv0981at 1097.420 kb on + strand, within Rv0981at 1097.420 kb on + strand, within Rv0981at 1097.421 kb on - strand, within Rv0981at 1097.421 kb on - strand, within Rv0981at 1097.421 kb on - strand, within Rv0981

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Isoniazid 0.025 ug/mL
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1,094,576 + -0.6
1,094,576 + +0.1
1,094,577 - +0.2
1,095,081 + +0.2
1,095,082 - -0.6
1,095,082 - +1.8
1,095,149 + +0.1
1,095,149 + -0.5
1,095,286 + Rv0980c 0.15 +1.2
1,095,286 + Rv0980c 0.15 +3.3
1,095,286 + Rv0980c 0.15 +1.0
1,095,287 - Rv0980c 0.15 +0.1
1,095,287 - Rv0980c 0.15 +1.1
1,095,287 - Rv0980c 0.15 +1.3
1,095,287 - Rv0980c 0.15 -0.8
1,095,287 - Rv0980c 0.15 -0.4
1,095,287 - Rv0980c 0.15 -0.3
1,095,287 - Rv0980c 0.15 -1.9
1,095,536 - Rv0980c 0.33 -2.4
1,095,536 - Rv0980c 0.33 +0.2
1,095,536 - Rv0980c 0.33 -1.4
1,095,536 - Rv0980c 0.33 +1.0
1,096,205 + Rv0980c 0.82 +0.6
1,096,205 + Rv0980c 0.82 -0.5
1,096,205 + Rv0980c 0.82 -0.6
1,096,768 + +0.1
1,096,769 - -0.6
1,096,769 - +0.3
1,097,114 - Rv0981 0.43 +0.9
1,097,118 - Rv0981 0.43 +2.4
1,097,118 - Rv0981 0.43 +0.0
1,097,364 - Rv0981 0.79 -1.5
1,097,364 - Rv0981 0.79 -1.2
1,097,416 + Rv0981 0.86 -2.0
1,097,417 - Rv0981 0.87 -0.2
1,097,420 + Rv0981 0.87 +2.2
1,097,420 + Rv0981 0.87 -0.2
1,097,421 - Rv0981 0.87 +0.7
1,097,421 - Rv0981 0.87 +0.4
1,097,421 - Rv0981 0.87 +0.4

Or see this region's nucleotide sequence