Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0491

Experiment: 7H9 with Isoniazid 0.025 ug/mL

Add experiment(s):

Zoom: Pan:

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

download SVG
500 ntRv0490 and Rv0491 are separated by 227 nucleotidesRv0491 and Rv0492c overlap by 4 nucleotides Rv0490: Rv0490 - Putative two component sensor histidine kinase SenX3, at 579,349 to 580,581 Rv0490 Rv0491: Rv0491 - Two component sensory transduction protein RegX3 (transcriptional regulatory protein) (probably LuxR-family), at 580,809 to 581,492 Rv0491 Rv0492c: Rv0492c - Probable oxidoreductase GMC-type, at 581,489 to 583,378 Rv0492c Position (kb) 580 581 582Strain fitness (log2 ratio) -3 -2 -1 0 1 2at 580.033 kb on - strand, within Rv0490at 580.411 kb on - strand, within Rv0490at 580.496 kb on - strandat 580.996 kb on + strand, within Rv0491at 580.996 kb on + strand, within Rv0491at 580.996 kb on + strand, within Rv0491at 580.996 kb on + strand, within Rv0491at 580.996 kb on + strand, within Rv0491at 580.997 kb on - strand, within Rv0491at 580.997 kb on - strand, within Rv0491at 580.997 kb on - strand, within Rv0491at 580.997 kb on - strand, within Rv0491at 580.997 kb on - strand, within Rv0491at 581.100 kb on + strand, within Rv0491at 581.368 kb on - strand, within Rv0491at 581.475 kb on + strandat 581.528 kb on + strandat 581.852 kb on + strand, within Rv0492cat 581.852 kb on + strand, within Rv0492cat 581.876 kb on + strand, within Rv0492cat 581.876 kb on + strand, within Rv0492cat 581.877 kb on - strand, within Rv0492cat 581.877 kb on - strand, within Rv0492cat 581.877 kb on - strand, within Rv0492cat 581.883 kb on + strand, within Rv0492cat 581.884 kb on - strand, within Rv0492cat 582.152 kb on - strand, within Rv0492cat 582.312 kb on + strand, within Rv0492cat 582.312 kb on + strand, within Rv0492c

download strain data

Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Isoniazid 0.025 ug/mL
remove
580,033 - Rv0490 0.55 -0.5
580,411 - Rv0490 0.86 +0.7
580,496 - -0.5
580,996 + Rv0491 0.27 -3.7
580,996 + Rv0491 0.27 +1.8
580,996 + Rv0491 0.27 -0.2
580,996 + Rv0491 0.27 -0.4
580,996 + Rv0491 0.27 +1.8
580,997 - Rv0491 0.27 -1.6
580,997 - Rv0491 0.27 -1.1
580,997 - Rv0491 0.27 -2.1
580,997 - Rv0491 0.27 -1.7
580,997 - Rv0491 0.27 -1.1
581,100 + Rv0491 0.43 +0.0
581,368 - Rv0491 0.82 -0.5
581,475 + -1.0
581,528 + -0.1
581,852 + Rv0492c 0.19 -0.9
581,852 + Rv0492c 0.19 -0.7
581,876 + Rv0492c 0.20 +0.8
581,876 + Rv0492c 0.20 -1.1
581,877 - Rv0492c 0.21 -0.3
581,877 - Rv0492c 0.21 +0.2
581,877 - Rv0492c 0.21 +0.2
581,883 + Rv0492c 0.21 -0.3
581,884 - Rv0492c 0.21 -0.5
582,152 - Rv0492c 0.35 -0.1
582,312 + Rv0492c 0.44 -2.2
582,312 + Rv0492c 0.44 -1.0

Or see this region's nucleotide sequence