Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0356c

Experiment: 7H9 with Isoniazid 0.025 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0355c and Rv0356c are separated by 150 nucleotidesRv0356c and Rv0357c overlap by 4 nucleotides Rv0355c: Rv0355c - PPE family protein PPE8, at 424,777 to 434,679 Rv0355c Rv0356c: Rv0356c - Conserved protein, at 434,830 to 435,474 Rv0356c Rv0357c: Rv0357c - Probable adenylosuccinate synthetase PurA (imp--aspartate ligase) (ADSS) (ampsase), at 435,471 to 436,769 Rv0357c Position (kb) 434 435 436Strain fitness (log2 ratio) -2 -1 0 1at 434.050 kb on - strandat 434.261 kb on + strandat 434.365 kb on + strandat 434.365 kb on + strandat 434.365 kb on + strandat 434.466 kb on - strandat 434.633 kb on + strandat 434.633 kb on + strandat 434.633 kb on + strandat 434.633 kb on + strandat 434.681 kb on + strandat 434.681 kb on + strandat 434.681 kb on + strandat 434.682 kb on - strandat 434.772 kb on + strandat 434.772 kb on + strandat 434.773 kb on - strandat 434.831 kb on + strandat 434.848 kb on + strandat 434.957 kb on - strand, within Rv0356cat 435.404 kb on + strand, within Rv0356c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Isoniazid 0.025 ug/mL
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434,050 - +0.1
434,261 + -0.6
434,365 + -2.4
434,365 + +0.1
434,365 + -0.6
434,466 - +0.2
434,633 + -0.3
434,633 + +0.2
434,633 + -0.3
434,633 + -1.2
434,681 + +0.1
434,681 + -0.7
434,681 + -0.8
434,682 - -0.1
434,772 + +1.5
434,772 + +0.2
434,773 - -0.9
434,831 + -0.0
434,848 + +0.5
434,957 - Rv0356c 0.20 -0.3
435,404 + Rv0356c 0.89 +0.6

Or see this region's nucleotide sequence