Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3843c

Experiment: 7H9 with Levofloxacin 0.3 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3841 and Rv3842c are separated by 14 nucleotidesRv3842c and Rv3843c are separated by 5 nucleotides Rv3841: Rv3841 - Bacterioferritin BfrB, at 4,314,178 to 4,314,723 Rv3841 Rv3842c: Rv3842c - Probable glycerophosphoryl diester phosphodiesterase GlpQ1 (glycerophosphodiester phosphodiesterase), at 4,314,738 to 4,315,562 Rv3842c Rv3843c: Rv3843c - Probable conserved transmembrane protein, at 4,315,568 to 4,316,596 Rv3843c Position (kb) 4315 4316 4317Strain fitness (log2 ratio) -3 -2 -1 0 1 2 3at 4314.644 kb on + strand, within Rv3841at 4314.644 kb on + strand, within Rv3841at 4314.645 kb on - strand, within Rv3841at 4314.721 kb on + strandat 4314.721 kb on + strandat 4314.722 kb on - strandat 4314.722 kb on - strandat 4314.803 kb on + strandat 4314.804 kb on - strandat 4314.851 kb on - strand, within Rv3842cat 4314.916 kb on + strand, within Rv3842cat 4314.917 kb on - strand, within Rv3842cat 4314.989 kb on - strand, within Rv3842cat 4315.129 kb on - strand, within Rv3842cat 4315.320 kb on + strand, within Rv3842cat 4315.320 kb on + strand, within Rv3842cat 4315.468 kb on + strand, within Rv3842cat 4315.469 kb on - strand, within Rv3842cat 4315.481 kb on + strandat 4315.481 kb on + strandat 4315.481 kb on + strandat 4315.481 kb on + strandat 4315.569 kb on + strandat 4315.570 kb on - strandat 4315.570 kb on - strandat 4316.003 kb on - strand, within Rv3843cat 4316.003 kb on - strand, within Rv3843cat 4316.340 kb on - strand, within Rv3843cat 4316.607 kb on + strandat 4316.724 kb on + strandat 4316.724 kb on + strandat 4316.724 kb on + strandat 4316.724 kb on + strandat 4316.725 kb on - strandat 4316.725 kb on - strandat 4316.725 kb on - strandat 4316.728 kb on + strandat 4316.756 kb on - strandat 4316.788 kb on + strandat 4316.789 kb on - strandat 4316.897 kb on + strandat 4316.898 kb on - strandat 4316.898 kb on - strandat 4316.926 kb on + strandat 4316.927 kb on - strandat 4317.029 kb on + strandat 4317.060 kb on + strandat 4317.060 kb on + strandat 4317.060 kb on + strandat 4317.061 kb on - strandat 4317.165 kb on - strandat 4317.250 kb on + strandat 4317.421 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Levofloxacin 0.3 ug/mL
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4,314,644 + Rv3841 0.85 -1.2
4,314,644 + Rv3841 0.85 +0.5
4,314,645 - Rv3841 0.86 -1.0
4,314,721 + -2.2
4,314,721 + +0.6
4,314,722 - -1.6
4,314,722 - -1.2
4,314,803 + -0.4
4,314,804 - +0.7
4,314,851 - Rv3842c 0.14 -0.3
4,314,916 + Rv3842c 0.22 +1.2
4,314,917 - Rv3842c 0.22 +0.6
4,314,989 - Rv3842c 0.30 +0.1
4,315,129 - Rv3842c 0.47 +2.6
4,315,320 + Rv3842c 0.71 +1.0
4,315,320 + Rv3842c 0.71 +0.0
4,315,468 + Rv3842c 0.88 +0.3
4,315,469 - Rv3842c 0.89 +0.1
4,315,481 + +1.0
4,315,481 + -0.5
4,315,481 + +0.3
4,315,481 + -1.6
4,315,569 + +0.8
4,315,570 - +1.1
4,315,570 - -0.1
4,316,003 - Rv3843c 0.42 +0.2
4,316,003 - Rv3843c 0.42 -1.6
4,316,340 - Rv3843c 0.75 -2.7
4,316,607 + +0.0
4,316,724 + -2.7
4,316,724 + -0.8
4,316,724 + -0.3
4,316,724 + +0.4
4,316,725 - +0.2
4,316,725 - +1.0
4,316,725 - -1.6
4,316,728 + -1.9
4,316,756 - -0.9
4,316,788 + -2.8
4,316,789 - -1.3
4,316,897 + +0.7
4,316,898 - -0.1
4,316,898 - -0.1
4,316,926 + -0.6
4,316,927 - -0.4
4,317,029 + +0.4
4,317,060 + +0.1
4,317,060 + -1.1
4,317,060 + -0.1
4,317,061 - +0.3
4,317,165 - -0.2
4,317,250 + +0.8
4,317,421 - +3.6

Or see this region's nucleotide sequence