Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3672c

Experiment: 7H9 with Levofloxacin 0.3 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3671c and Rv3672c are separated by 5 nucleotidesRv3672c and Rv3673c are separated by 131 nucleotidesRv3673c and Rv3674c overlap by 1 nucleotides Rv3671c: Rv3671c - Membrane-associated serine protease, at 4,112,322 to 4,113,515 Rv3671c Rv3672c: Rv3672c - Conserved hypothetical protein, at 4,113,521 to 4,114,342 Rv3672c Rv3673c: Rv3673c - Possible membrane-anchored thioredoxin-like protein (thiol-disulfide interchange related protein), at 4,114,474 to 4,115,157 Rv3673c Rv3674c: Rv3674c - Probable endonuclease III Nth (DNA-(apurinic or apyrimidinic site)lyase) (AP lyase) (AP endonuclease class I) (endodeoxyribonuclease (apurinic or apyrimidinic)) (deoxyribonuclease (apurinic or apyrimidinic)), at 4,115,157 to 4,115,894 Rv3674c Position (kb) 4113 4114 4115Strain fitness (log2 ratio) -1 0 1at 4114.041 kb on - strand, within Rv3672cat 4114.041 kb on - strand, within Rv3672cat 4114.218 kb on - strand, within Rv3672cat 4114.471 kb on + strandat 4115.158 kb on + strandat 4115.159 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Levofloxacin 0.3 ug/mL
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4,114,041 - Rv3672c 0.63 -0.0
4,114,041 - Rv3672c 0.63 -1.2
4,114,218 - Rv3672c 0.85 -0.6
4,114,471 + -0.6
4,115,158 + -1.0
4,115,159 - +0.0

Or see this region's nucleotide sequence