Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3480c

Experiment: 7H9 with Levofloxacin 0.3 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3479 and Rv3480c are separated by 23 nucleotidesRv3480c and Rv3481c are separated by 90 nucleotidesRv3481c and Rv3482c are separated by 141 nucleotides Rv3479: Rv3479 - Possible transmembrane protein, at 3,895,820 to 3,898,885 Rv3479 Rv3480c: Rv3480c - Possible triacylglycerol synthase (diacylglycerol acyltransferase), at 3,898,909 to 3,900,402 Rv3480c Rv3481c: Rv3481c - Probable integral membrane protein, at 3,900,493 to 3,901,182 Rv3481c Rv3482c: Rv3482c - Probable conserved membrane protein, at 3,901,324 to 3,902,106 Rv3482c Position (kb) 3898 3899 3900 3901Strain fitness (log2 ratio) -3 -2 -1 0 1 2at 3898.269 kb on + strand, within Rv3479at 3898.438 kb on - strand, within Rv3479at 3898.545 kb on + strand, within Rv3479at 3898.731 kb on + strandat 3899.042 kb on + strandat 3899.252 kb on + strand, within Rv3480cat 3899.617 kb on + strand, within Rv3480cat 3899.618 kb on - strand, within Rv3480cat 3899.741 kb on - strand, within Rv3480cat 3899.824 kb on + strand, within Rv3480cat 3899.824 kb on + strand, within Rv3480cat 3899.991 kb on - strand, within Rv3480cat 3900.143 kb on + strand, within Rv3480cat 3900.143 kb on + strand, within Rv3480cat 3900.191 kb on + strand, within Rv3480cat 3900.194 kb on - strand, within Rv3480cat 3900.453 kb on - strandat 3900.457 kb on - strandat 3900.457 kb on - strandat 3900.461 kb on + strandat 3900.462 kb on - strandat 3900.516 kb on - strandat 3900.526 kb on + strandat 3900.588 kb on + strand, within Rv3481cat 3901.066 kb on + strand, within Rv3481cat 3901.259 kb on + strandat 3901.290 kb on + strandat 3901.291 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Levofloxacin 0.3 ug/mL
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3,898,269 + Rv3479 0.80 +0.8
3,898,438 - Rv3479 0.85 -0.7
3,898,545 + Rv3479 0.89 -0.6
3,898,731 + -0.1
3,899,042 + +0.9
3,899,252 + Rv3480c 0.23 -1.4
3,899,617 + Rv3480c 0.47 -0.6
3,899,618 - Rv3480c 0.47 -3.1
3,899,741 - Rv3480c 0.56 -0.7
3,899,824 + Rv3480c 0.61 -0.9
3,899,824 + Rv3480c 0.61 -0.8
3,899,991 - Rv3480c 0.72 -0.8
3,900,143 + Rv3480c 0.83 -0.2
3,900,143 + Rv3480c 0.83 -3.0
3,900,191 + Rv3480c 0.86 +1.0
3,900,194 - Rv3480c 0.86 -0.5
3,900,453 - -0.7
3,900,457 - -1.8
3,900,457 - +0.2
3,900,461 + -0.2
3,900,462 - +0.7
3,900,516 - +2.0
3,900,526 + +0.4
3,900,588 + Rv3481c 0.14 +1.2
3,901,066 + Rv3481c 0.83 -0.2
3,901,259 + -0.3
3,901,290 + -1.2
3,901,291 - -0.0

Or see this region's nucleotide sequence