Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3114

Experiment: 7H9 with Levofloxacin 0.3 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3112 and Rv3113 are separated by 122 nucleotidesRv3113 and Rv3114 are separated by 16 nucleotidesRv3114 and Rv3115 are separated by 161 nucleotides Rv3112: Rv3112 - Probable molybdenum cofactor biosynthesis protein D MoaD1 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor, subunit 1), at 3,479,700 to 3,479,951 Rv3112 Rv3113: Rv3113 - Possible phosphatase, at 3,480,074 to 3,480,742 Rv3113 Rv3114: Rv3114 - Conserved hypothetical protein, at 3,480,759 to 3,481,289 Rv3114 Rv3115: Rv3115 - Probable transposase, at 3,481,451 to 3,482,698 Rv3115 Position (kb) 3480 3481 3482Strain fitness (log2 ratio) -1 0 1at 3480.719 kb on + strandat 3480.753 kb on - strandat 3480.931 kb on - strand, within Rv3114at 3481.305 kb on - strandat 3481.330 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Levofloxacin 0.3 ug/mL
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3,480,719 + -0.7
3,480,753 - -0.5
3,480,931 - Rv3114 0.32 -1.0
3,481,305 - +0.9
3,481,330 - -0.3

Or see this region's nucleotide sequence