Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2949c

Experiment: 7H9 with Levofloxacin 0.3 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2948c and Rv2949c are separated by 16 nucleotidesRv2949c and Rv2950c are separated by 25 nucleotides Rv2948c: Rv2948c - P-hydroxybenzoyl-AMP ligase FadD22, at 3,297,837 to 3,299,954 Rv2948c Rv2949c: Rv2949c - Chorismate pyruvate lyase, at 3,299,971 to 3,300,570 Rv2949c Rv2950c: Rv2950c - Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase), at 3,300,596 to 3,302,455 Rv2950c Position (kb) 3299 3300 3301Strain fitness (log2 ratio) -2 -1 0 1 2 3at 3299.070 kb on - strand, within Rv2948cat 3299.365 kb on + strand, within Rv2948cat 3299.378 kb on + strand, within Rv2948cat 3299.382 kb on + strand, within Rv2948cat 3299.417 kb on + strand, within Rv2948cat 3299.426 kb on + strand, within Rv2948cat 3299.426 kb on + strand, within Rv2948cat 3299.427 kb on - strand, within Rv2948cat 3299.427 kb on - strand, within Rv2948cat 3299.427 kb on - strand, within Rv2948cat 3299.489 kb on + strand, within Rv2948cat 3299.498 kb on + strand, within Rv2948cat 3299.498 kb on + strand, within Rv2948cat 3299.498 kb on + strand, within Rv2948cat 3299.498 kb on + strand, within Rv2948cat 3299.498 kb on + strand, within Rv2948cat 3299.499 kb on - strand, within Rv2948cat 3299.499 kb on - strand, within Rv2948cat 3299.499 kb on - strand, within Rv2948cat 3299.500 kb on + strand, within Rv2948cat 3299.500 kb on + strand, within Rv2948cat 3299.500 kb on + strand, within Rv2948cat 3299.500 kb on + strand, within Rv2948cat 3299.500 kb on + strand, within Rv2948cat 3299.500 kb on + strand, within Rv2948cat 3299.501 kb on - strand, within Rv2948cat 3299.501 kb on - strand, within Rv2948cat 3299.501 kb on - strand, within Rv2948cat 3299.501 kb on - strand, within Rv2948cat 3299.501 kb on - strand, within Rv2948cat 3299.504 kb on + strand, within Rv2948cat 3299.504 kb on + strand, within Rv2948cat 3299.504 kb on + strand, within Rv2948cat 3299.505 kb on - strand, within Rv2948cat 3299.505 kb on - strand, within Rv2948cat 3299.505 kb on - strand, within Rv2948cat 3299.509 kb on + strand, within Rv2948cat 3299.509 kb on + strand, within Rv2948cat 3299.509 kb on + strand, within Rv2948cat 3299.509 kb on + strand, within Rv2948cat 3299.510 kb on - strand, within Rv2948cat 3299.510 kb on - strand, within Rv2948cat 3299.539 kb on + strand, within Rv2948cat 3299.539 kb on + strand, within Rv2948cat 3299.742 kb on + strand, within Rv2948cat 3299.742 kb on + strand, within Rv2948cat 3299.878 kb on + strandat 3299.878 kb on + strandat 3299.879 kb on - strandat 3299.896 kb on + strandat 3299.896 kb on + strandat 3299.897 kb on - strandat 3299.957 kb on - strandat 3300.138 kb on - strand, within Rv2949cat 3300.262 kb on + strand, within Rv2949cat 3300.339 kb on + strand, within Rv2949cat 3300.344 kb on - strand, within Rv2949cat 3300.586 kb on - strandat 3300.688 kb on + strandat 3300.743 kb on + strandat 3300.924 kb on + strand, within Rv2950cat 3301.215 kb on + strand, within Rv2950cat 3301.215 kb on + strand, within Rv2950cat 3301.215 kb on + strand, within Rv2950cat 3301.215 kb on + strand, within Rv2950cat 3301.216 kb on - strand, within Rv2950cat 3301.216 kb on - strand, within Rv2950cat 3301.284 kb on + strand, within Rv2950cat 3301.285 kb on - strand, within Rv2950cat 3301.285 kb on - strand, within Rv2950cat 3301.335 kb on + strand, within Rv2950cat 3301.336 kb on - strand, within Rv2950cat 3301.360 kb on - strand, within Rv2950cat 3301.437 kb on - strand, within Rv2950c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Levofloxacin 0.3 ug/mL
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3,299,070 - Rv2948c 0.58 -2.0
3,299,365 + Rv2948c 0.72 +0.1
3,299,378 + Rv2948c 0.73 +1.5
3,299,382 + Rv2948c 0.73 +0.4
3,299,417 + Rv2948c 0.75 -1.0
3,299,426 + Rv2948c 0.75 -0.1
3,299,426 + Rv2948c 0.75 -1.0
3,299,427 - Rv2948c 0.75 -0.5
3,299,427 - Rv2948c 0.75 -0.0
3,299,427 - Rv2948c 0.75 -0.1
3,299,489 + Rv2948c 0.78 +0.6
3,299,498 + Rv2948c 0.78 +0.1
3,299,498 + Rv2948c 0.78 -0.2
3,299,498 + Rv2948c 0.78 -0.5
3,299,498 + Rv2948c 0.78 -0.4
3,299,498 + Rv2948c 0.78 -1.3
3,299,499 - Rv2948c 0.78 +0.3
3,299,499 - Rv2948c 0.78 +3.2
3,299,499 - Rv2948c 0.78 -1.1
3,299,500 + Rv2948c 0.79 -1.5
3,299,500 + Rv2948c 0.79 -1.4
3,299,500 + Rv2948c 0.79 -0.3
3,299,500 + Rv2948c 0.79 -1.4
3,299,500 + Rv2948c 0.79 -0.8
3,299,500 + Rv2948c 0.79 -0.5
3,299,501 - Rv2948c 0.79 +2.2
3,299,501 - Rv2948c 0.79 -0.6
3,299,501 - Rv2948c 0.79 -1.4
3,299,501 - Rv2948c 0.79 +1.6
3,299,501 - Rv2948c 0.79 +1.2
3,299,504 + Rv2948c 0.79 -0.9
3,299,504 + Rv2948c 0.79 +0.4
3,299,504 + Rv2948c 0.79 -0.6
3,299,505 - Rv2948c 0.79 -1.5
3,299,505 - Rv2948c 0.79 -0.3
3,299,505 - Rv2948c 0.79 +0.2
3,299,509 + Rv2948c 0.79 -0.0
3,299,509 + Rv2948c 0.79 -0.8
3,299,509 + Rv2948c 0.79 +1.2
3,299,509 + Rv2948c 0.79 -0.3
3,299,510 - Rv2948c 0.79 -1.0
3,299,510 - Rv2948c 0.79 +2.2
3,299,539 + Rv2948c 0.80 -0.7
3,299,539 + Rv2948c 0.80 -0.2
3,299,742 + Rv2948c 0.90 +1.5
3,299,742 + Rv2948c 0.90 -0.2
3,299,878 + -0.1
3,299,878 + -0.7
3,299,879 - -0.6
3,299,896 + +0.2
3,299,896 + +0.8
3,299,897 - +1.4
3,299,957 - +0.1
3,300,138 - Rv2949c 0.28 -2.0
3,300,262 + Rv2949c 0.48 -0.2
3,300,339 + Rv2949c 0.61 -2.2
3,300,344 - Rv2949c 0.62 +2.2
3,300,586 - -0.2
3,300,688 + +0.7
3,300,743 + +0.8
3,300,924 + Rv2950c 0.18 +1.2
3,301,215 + Rv2950c 0.33 -0.8
3,301,215 + Rv2950c 0.33 -1.4
3,301,215 + Rv2950c 0.33 -2.1
3,301,215 + Rv2950c 0.33 -2.0
3,301,216 - Rv2950c 0.33 -0.4
3,301,216 - Rv2950c 0.33 -0.3
3,301,284 + Rv2950c 0.37 +1.1
3,301,285 - Rv2950c 0.37 -1.6
3,301,285 - Rv2950c 0.37 -0.4
3,301,335 + Rv2950c 0.40 -0.1
3,301,336 - Rv2950c 0.40 -0.9
3,301,360 - Rv2950c 0.41 -1.0
3,301,437 - Rv2950c 0.45 -0.5

Or see this region's nucleotide sequence