Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2737c

Experiment: 7H9 with Levofloxacin 0.3 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2735c and Rv2736c are separated by 9 nucleotidesRv2736c and Rv2737c overlap by 35 nucleotidesRv2737c and Rv2737A are separated by 194 nucleotidesRv2737A and Rv2738c are separated by 13 nucleotidesRv2738c and Rv2739c are separated by 10 nucleotides Rv2735c: Rv2735c - Conserved hypothetical protein, at 3,047,560 to 3,048,552 Rv2735c Rv2736c: Rv2736c - Regulatory protein RecX, at 3,048,562 to 3,049,086 Rv2736c Rv2737c: Rv2737c - RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]., at 3,049,052 to 3,051,424 Rv2737c Rv2737A: Rv2737A - Conserved hypothetical cysteine rich protein (fragment), at 3,051,619 to 3,051,792 Rv2737A Rv2738c: Rv2738c - Conserved hypothetical protein, at 3,051,806 to 3,052,012 Rv2738c Rv2739c: Rv2739c - Possible alanine rich transferase, at 3,052,023 to 3,053,189 Rv2739c Position (kb) 3049 3050 3051 3052Strain fitness (log2 ratio) -3 -2 -1 0 1 2at 3048.086 kb on - strand, within Rv2735cat 3048.208 kb on + strand, within Rv2735cat 3048.208 kb on + strand, within Rv2735cat 3048.497 kb on + strandat 3048.508 kb on + strandat 3048.547 kb on - strandat 3048.728 kb on - strand, within Rv2736cat 3049.550 kb on + strand, within Rv2737cat 3049.551 kb on - strand, within Rv2737cat 3049.551 kb on - strand, within Rv2737cat 3049.551 kb on - strand, within Rv2737cat 3049.678 kb on - strand, within Rv2737cat 3049.678 kb on - strand, within Rv2737cat 3049.678 kb on - strand, within Rv2737cat 3049.678 kb on - strand, within Rv2737cat 3050.182 kb on + strand, within Rv2737cat 3050.183 kb on - strand, within Rv2737cat 3050.436 kb on + strand, within Rv2737cat 3050.629 kb on + strand, within Rv2737cat 3050.769 kb on + strand, within Rv2737cat 3050.873 kb on - strand, within Rv2737cat 3051.228 kb on + strandat 3051.228 kb on + strandat 3051.229 kb on - strandat 3051.230 kb on + strandat 3051.230 kb on + strandat 3051.230 kb on + strandat 3051.236 kb on + strandat 3051.282 kb on - strandat 3051.361 kb on - strandat 3051.483 kb on + strandat 3051.484 kb on - strandat 3051.749 kb on - strand, within Rv2737Aat 3052.013 kb on - strandat 3052.013 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Levofloxacin 0.3 ug/mL
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3,048,086 - Rv2735c 0.53 +0.5
3,048,208 + Rv2735c 0.65 +1.8
3,048,208 + Rv2735c 0.65 -0.4
3,048,497 + +0.8
3,048,508 + -1.0
3,048,547 - -1.4
3,048,728 - Rv2736c 0.32 -0.6
3,049,550 + Rv2737c 0.21 -1.2
3,049,551 - Rv2737c 0.21 -1.4
3,049,551 - Rv2737c 0.21 -3.1
3,049,551 - Rv2737c 0.21 -1.5
3,049,678 - Rv2737c 0.26 -2.6
3,049,678 - Rv2737c 0.26 +2.2
3,049,678 - Rv2737c 0.26 +0.2
3,049,678 - Rv2737c 0.26 -0.4
3,050,182 + Rv2737c 0.48 -1.2
3,050,183 - Rv2737c 0.48 -1.0
3,050,436 + Rv2737c 0.58 -1.5
3,050,629 + Rv2737c 0.66 -0.1
3,050,769 + Rv2737c 0.72 +0.6
3,050,873 - Rv2737c 0.77 -0.6
3,051,228 + +0.0
3,051,228 + -1.2
3,051,229 - -1.1
3,051,230 + -2.5
3,051,230 + -1.0
3,051,230 + +0.4
3,051,236 + +1.2
3,051,282 - -2.0
3,051,361 - -1.1
3,051,483 + -1.2
3,051,484 - +1.6
3,051,749 - Rv2737A 0.75 +2.6
3,052,013 - +0.6
3,052,013 - +1.8

Or see this region's nucleotide sequence