Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2277c

Experiment: 7H9 with Levofloxacin 0.3 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2276 and Rv2277c are separated by 184 nucleotidesRv2277c and Rv2278 are separated by 35 nucleotidesRv2278 and Rv2279 overlap by 52 nucleotides Rv2276: Rv2276 - Cytochrome P450 121 Cyp121, at 2,547,749 to 2,548,939 Rv2276 Rv2277c: Rv2277c - Possible glycerolphosphodiesterase, at 2,549,124 to 2,550,029 Rv2277c Rv2278: Rv2278 - Putative transposase for insertion sequence element IS6110 (fragment), at 2,550,065 to 2,550,391 Rv2278 Rv2279: Rv2279 - Probable transposase, at 2,550,340 to 2,551,326 Rv2279 Position (kb) 2549 2550 2551Strain fitness (log2 ratio) -1 0 1at 2548.234 kb on + strand, within Rv2276at 2548.497 kb on + strand, within Rv2276at 2549.512 kb on - strand, within Rv2277cat 2549.598 kb on + strand, within Rv2277cat 2549.598 kb on + strand, within Rv2277cat 2549.800 kb on + strand, within Rv2277cat 2549.877 kb on - strand, within Rv2277c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Levofloxacin 0.3 ug/mL
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2,548,234 + Rv2276 0.41 +0.9
2,548,497 + Rv2276 0.63 -0.7
2,549,512 - Rv2277c 0.43 -0.3
2,549,598 + Rv2277c 0.52 -0.3
2,549,598 + Rv2277c 0.52 -0.0
2,549,800 + Rv2277c 0.75 -0.3
2,549,877 - Rv2277c 0.83 -0.4

Or see this region's nucleotide sequence