Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2269c

Experiment: 7H9 with Levofloxacin 0.3 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2268c and Rv2269c are separated by 12 nucleotidesRv2269c and Rv2270 are separated by 76 nucleotidesRv2270 and Rv2271 are separated by 106 nucleotides Rv2268c: Rv2268c - Probable cytochrome P450 128 Cyp128, at 2,542,807 to 2,544,276 Rv2268c Rv2269c: Rv2269c - Hypothetical protein, at 2,544,289 to 2,544,621 Rv2269c Rv2270: Rv2270 - Probable lipoprotein LppN, at 2,544,698 to 2,545,225 Rv2270 Rv2271: Rv2271 - Conserved hypothetical protein, at 2,545,332 to 2,545,631 Rv2271 Position (kb) 2544 2545Strain fitness (log2 ratio) -2 -1 0 1at 2543.833 kb on - strand, within Rv2268cat 2543.873 kb on + strand, within Rv2268cat 2543.895 kb on - strand, within Rv2268cat 2544.300 kb on + strandat 2544.371 kb on - strand, within Rv2269cat 2544.371 kb on - strand, within Rv2269cat 2544.491 kb on + strand, within Rv2269cat 2544.491 kb on + strand, within Rv2269cat 2544.545 kb on + strand, within Rv2269cat 2544.678 kb on - strandat 2544.725 kb on + strandat 2544.726 kb on - strandat 2544.726 kb on - strandat 2544.992 kb on + strand, within Rv2270at 2545.113 kb on - strand, within Rv2270at 2545.136 kb on - strand, within Rv2270at 2545.308 kb on + strandat 2545.455 kb on + strand, within Rv2271at 2545.578 kb on + strand, within Rv2271at 2545.597 kb on + strand, within Rv2271at 2545.598 kb on - strand, within Rv2271

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Levofloxacin 0.3 ug/mL
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2,543,833 - Rv2268c 0.70 -1.0
2,543,873 + Rv2268c 0.73 +0.4
2,543,895 - Rv2268c 0.74 -1.9
2,544,300 + +0.8
2,544,371 - Rv2269c 0.25 -1.9
2,544,371 - Rv2269c 0.25 -0.8
2,544,491 + Rv2269c 0.61 -1.3
2,544,491 + Rv2269c 0.61 -0.8
2,544,545 + Rv2269c 0.77 -1.3
2,544,678 - -0.8
2,544,725 + +0.2
2,544,726 - +0.5
2,544,726 - -0.8
2,544,992 + Rv2270 0.56 +0.7
2,545,113 - Rv2270 0.79 -1.0
2,545,136 - Rv2270 0.83 -1.3
2,545,308 + +0.4
2,545,455 + Rv2271 0.41 +0.7
2,545,578 + Rv2271 0.82 +1.3
2,545,597 + Rv2271 0.88 -0.4
2,545,598 - Rv2271 0.89 -0.2

Or see this region's nucleotide sequence