Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2261c

Experiment: 7H9 with Levofloxacin 0.3 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2259 and Rv2260 overlap by 1 nucleotidesRv2260 and Rv2261c are separated by 76 nucleotidesRv2261c and Rv2262c are separated by 5 nucleotides Rv2259: Rv2259 - S-nitrosomycothiol reductase MscR, at 2,532,245 to 2,533,330 Rv2259 Rv2260: Rv2260 - Conserved hypothetical protein, at 2,533,330 to 2,533,965 Rv2260 Rv2261c: Rv2261c - Conserved hypothetical protein, at 2,534,042 to 2,534,464 Rv2261c Rv2262c: Rv2262c - Conserved hypothetical protein, at 2,534,470 to 2,535,552 Rv2262c Position (kb) 2534 2535Strain fitness (log2 ratio) -3 -2 -1 0 1at 2533.209 kb on - strand, within Rv2259at 2533.305 kb on + strandat 2533.305 kb on + strandat 2533.306 kb on - strandat 2533.868 kb on + strand, within Rv2260at 2534.011 kb on + strandat 2534.012 kb on - strandat 2534.243 kb on - strand, within Rv2261cat 2534.377 kb on - strand, within Rv2261cat 2534.571 kb on - strandat 2534.571 kb on - strandat 2534.603 kb on + strand, within Rv2262cat 2534.603 kb on + strand, within Rv2262cat 2534.648 kb on + strand, within Rv2262cat 2534.649 kb on - strand, within Rv2262cat 2534.649 kb on - strand, within Rv2262cat 2534.875 kb on + strand, within Rv2262cat 2534.927 kb on + strand, within Rv2262cat 2534.928 kb on - strand, within Rv2262cat 2535.025 kb on - strand, within Rv2262cat 2535.082 kb on + strand, within Rv2262cat 2535.330 kb on - strand, within Rv2262c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Levofloxacin 0.3 ug/mL
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2,533,209 - Rv2259 0.89 -1.9
2,533,305 + -0.3
2,533,305 + -3.2
2,533,306 - +0.3
2,533,868 + Rv2260 0.85 -0.1
2,534,011 + +0.5
2,534,012 - +1.3
2,534,243 - Rv2261c 0.48 -0.3
2,534,377 - Rv2261c 0.79 +1.6
2,534,571 - +0.1
2,534,571 - -1.4
2,534,603 + Rv2262c 0.12 +1.5
2,534,603 + Rv2262c 0.12 -1.3
2,534,648 + Rv2262c 0.16 -0.1
2,534,649 - Rv2262c 0.17 -0.7
2,534,649 - Rv2262c 0.17 -1.2
2,534,875 + Rv2262c 0.37 -0.8
2,534,927 + Rv2262c 0.42 +1.5
2,534,928 - Rv2262c 0.42 -0.5
2,535,025 - Rv2262c 0.51 -0.0
2,535,082 + Rv2262c 0.57 -0.1
2,535,330 - Rv2262c 0.79 -0.6

Or see this region's nucleotide sequence