Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2231c

Experiment: 7H9 with Levofloxacin 0.3 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2230c and Rv2231c overlap by 4 nucleotidesRv2231c and Rv2231A are separated by 36 nucleotidesRv2231A and Rv2231B are separated by 45 nucleotidesRv2231B and Rv2232 overlap by 106 nucleotides Rv2230c: Rv2230c - Conserved protein, at 2,503,469 to 2,504,608 Rv2230c Rv2231c: Rv2231c - Possible aminotransferase CobC, at 2,504,605 to 2,505,699 Rv2231c Rv2231A: Rv2231A - Possible toxin VapC16, at 2,505,736 to 2,506,161 Rv2231A Rv2231B: Rv2231B - Possible antitoxin VapB16, at 2,506,207 to 2,506,383 Rv2231B Rv2232: Rv2232 - Protein tyrosine kinase transcriptional regulatory protein PtkA, at 2,506,278 to 2,507,153 Rv2232 Position (kb) 2504 2505 2506Strain fitness (log2 ratio) -3 -2 -1 0 1 2at 2504.191 kb on - strand, within Rv2230cat 2505.009 kb on - strand, within Rv2231cat 2505.641 kb on - strandat 2505.641 kb on - strandat 2505.664 kb on + strandat 2505.665 kb on - strandat 2505.747 kb on + strandat 2505.748 kb on - strandat 2505.748 kb on - strandat 2505.915 kb on - strand, within Rv2231Aat 2505.915 kb on - strand, within Rv2231Aat 2506.076 kb on - strand, within Rv2231Aat 2506.371 kb on - strandat 2506.570 kb on + strand, within Rv2232

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Levofloxacin 0.3 ug/mL
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2,504,191 - Rv2230c 0.63 -2.9
2,505,009 - Rv2231c 0.37 -1.1
2,505,641 - +2.3
2,505,641 - -0.2
2,505,664 + +1.3
2,505,665 - -0.4
2,505,747 + -0.6
2,505,748 - -1.3
2,505,748 - -1.0
2,505,915 - Rv2231A 0.42 +0.3
2,505,915 - Rv2231A 0.42 +0.9
2,506,076 - Rv2231A 0.80 -2.5
2,506,371 - +1.5
2,506,570 + Rv2232 0.33 +0.6

Or see this region's nucleotide sequence