Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2037c

Experiment: 7H9 with Levofloxacin 0.3 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2035 and Rv2036 overlap by 4 nucleotidesRv2036 and Rv2037c are separated by 6 nucleotidesRv2037c and Rv2038c are separated by 1 nucleotides Rv2035: Rv2035 - Conserved hypothetical protein, at 2,281,614 to 2,282,102 Rv2035 Rv2036: Rv2036 - Conserved hypothetical protein, at 2,282,099 to 2,282,740 Rv2036 Rv2037c: Rv2037c - Conserved transmembrane protein, at 2,282,747 to 2,283,721 Rv2037c Rv2038c: Rv2038c - Probable sugar-transport ATP-binding protein ABC transporter, at 2,283,723 to 2,284,796 Rv2038c Position (kb) 2282 2283 2284Strain fitness (log2 ratio) -2 -1 0 1at 2281.785 kb on - strand, within Rv2035at 2281.788 kb on + strand, within Rv2035at 2281.839 kb on + strand, within Rv2035at 2281.840 kb on - strand, within Rv2035at 2281.861 kb on + strand, within Rv2035at 2282.055 kb on + strandat 2282.056 kb on - strandat 2282.059 kb on + strandat 2282.068 kb on - strandat 2282.070 kb on - strandat 2282.166 kb on + strand, within Rv2036at 2282.748 kb on + strandat 2282.788 kb on - strandat 2283.281 kb on + strand, within Rv2037cat 2283.281 kb on + strand, within Rv2037cat 2283.282 kb on - strand, within Rv2037cat 2283.499 kb on - strand, within Rv2037cat 2283.880 kb on + strand, within Rv2038cat 2283.886 kb on + strand, within Rv2038cat 2284.225 kb on + strand, within Rv2038cat 2284.653 kb on + strand, within Rv2038c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Levofloxacin 0.3 ug/mL
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2,281,785 - Rv2035 0.35 -0.9
2,281,788 + Rv2035 0.36 -2.0
2,281,839 + Rv2035 0.46 -1.3
2,281,840 - Rv2035 0.46 +0.8
2,281,861 + Rv2035 0.51 +0.1
2,282,055 + +0.1
2,282,056 - +0.0
2,282,059 + -0.1
2,282,068 - +0.9
2,282,070 - -0.6
2,282,166 + Rv2036 0.10 -0.2
2,282,748 + -1.2
2,282,788 - +0.1
2,283,281 + Rv2037c 0.55 -1.1
2,283,281 + Rv2037c 0.55 -0.5
2,283,282 - Rv2037c 0.55 -0.7
2,283,499 - Rv2037c 0.77 -0.6
2,283,880 + Rv2038c 0.15 -0.2
2,283,886 + Rv2038c 0.15 -0.6
2,284,225 + Rv2038c 0.47 -0.5
2,284,653 + Rv2038c 0.87 -0.4

Or see this region's nucleotide sequence