Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1962A

Experiment: 7H9 with Levofloxacin 0.3 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1961 and Rv1962c are separated by 159 nucleotidesRv1962c and Rv1962A are separated by 3 nucleotidesRv1962A and Rv1963c are separated by 32 nucleotides Rv1961: Rv1961 - Hypothetical protein, at 2,204,212 to 2,204,706 Rv1961 Rv1962c: Rv1962c - Possible toxin VapC35. Contains PIN domain., at 2,204,866 to 2,205,273 Rv1962c Rv1962A: Rv1962A - Possible antitoxin VapB35, at 2,205,277 to 2,205,549 Rv1962A Rv1963c: Rv1963c - Probable transcriptional repressor (probably TetR-family) Mce3R, at 2,205,582 to 2,206,802 Rv1963c Position (kb) 2205 2206Strain fitness (log2 ratio) -2 -1 0 1 2 3at 2204.389 kb on + strand, within Rv1961at 2204.390 kb on - strand, within Rv1961at 2204.401 kb on + strand, within Rv1961at 2204.402 kb on - strand, within Rv1961at 2204.402 kb on - strand, within Rv1961at 2204.402 kb on - strand, within Rv1961at 2204.638 kb on + strand, within Rv1961at 2204.728 kb on + strandat 2204.783 kb on - strandat 2204.787 kb on + strandat 2204.923 kb on - strand, within Rv1962cat 2204.936 kb on + strand, within Rv1962cat 2204.937 kb on - strand, within Rv1962cat 2204.989 kb on + strand, within Rv1962cat 2204.989 kb on + strand, within Rv1962cat 2204.995 kb on + strand, within Rv1962cat 2205.049 kb on + strand, within Rv1962cat 2205.143 kb on - strand, within Rv1962cat 2205.143 kb on - strand, within Rv1962cat 2205.143 kb on - strand, within Rv1962cat 2205.208 kb on + strand, within Rv1962cat 2205.238 kb on + strandat 2205.267 kb on - strandat 2205.281 kb on + strandat 2205.437 kb on - strand, within Rv1962Aat 2205.599 kb on + strandat 2205.599 kb on + strandat 2205.599 kb on + strandat 2205.600 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Levofloxacin 0.3 ug/mL
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2,204,389 + Rv1961 0.36 -0.2
2,204,390 - Rv1961 0.36 -0.2
2,204,401 + Rv1961 0.38 -0.6
2,204,402 - Rv1961 0.38 +0.8
2,204,402 - Rv1961 0.38 -0.6
2,204,402 - Rv1961 0.38 -1.2
2,204,638 + Rv1961 0.86 -0.7
2,204,728 + -0.4
2,204,783 - +1.1
2,204,787 + -0.8
2,204,923 - Rv1962c 0.14 -0.6
2,204,936 + Rv1962c 0.17 +0.9
2,204,937 - Rv1962c 0.17 -2.7
2,204,989 + Rv1962c 0.30 -0.2
2,204,989 + Rv1962c 0.30 +1.1
2,204,995 + Rv1962c 0.32 +3.7
2,205,049 + Rv1962c 0.45 +0.8
2,205,143 - Rv1962c 0.68 -0.8
2,205,143 - Rv1962c 0.68 -0.5
2,205,143 - Rv1962c 0.68 -0.3
2,205,208 + Rv1962c 0.84 -0.1
2,205,238 + -0.4
2,205,267 - -0.2
2,205,281 + -0.5
2,205,437 - Rv1962A 0.59 -1.8
2,205,599 + -0.1
2,205,599 + -0.9
2,205,599 + -0.4
2,205,600 - +0.1

Or see this region's nucleotide sequence