Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1939

Experiment: 7H9 with Levofloxacin 0.3 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1938 and Rv1939 overlap by 4 nucleotidesRv1939 and Rv1940 overlap by 4 nucleotides Rv1938: Rv1938 - Probable epoxide hydrolase EphB (epoxide hydratase), at 2,191,027 to 2,192,097 Rv1938 Rv1939: Rv1939 - Probable oxidoreductase, at 2,192,094 to 2,192,609 Rv1939 Rv1940: Rv1940 - Probable riboflavin biosynthesis protein RibA1 (GTP cyclohydrolase II), at 2,192,606 to 2,193,667 Rv1940 Position (kb) 2192 2193Strain fitness (log2 ratio) -2 -1 0 1at 2191.238 kb on - strand, within Rv1938at 2191.597 kb on + strand, within Rv1938at 2191.597 kb on + strand, within Rv1938at 2191.708 kb on - strand, within Rv1938at 2191.927 kb on + strand, within Rv1938at 2192.372 kb on + strand, within Rv1939at 2192.372 kb on + strand, within Rv1939at 2192.373 kb on - strand, within Rv1939at 2192.700 kb on - strandat 2193.465 kb on - strand, within Rv1940at 2193.465 kb on - strand, within Rv1940at 2193.465 kb on - strand, within Rv1940at 2193.575 kb on + strandat 2193.575 kb on + strandat 2193.575 kb on + strandat 2193.575 kb on + strandat 2193.576 kb on - strandat 2193.576 kb on - strandat 2193.576 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Levofloxacin 0.3 ug/mL
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2,191,238 - Rv1938 0.20 +1.4
2,191,597 + Rv1938 0.53 -1.5
2,191,597 + Rv1938 0.53 +0.8
2,191,708 - Rv1938 0.64 -0.6
2,191,927 + Rv1938 0.84 -0.9
2,192,372 + Rv1939 0.54 -1.2
2,192,372 + Rv1939 0.54 -2.3
2,192,373 - Rv1939 0.54 -0.6
2,192,700 - +1.7
2,193,465 - Rv1940 0.81 -0.2
2,193,465 - Rv1940 0.81 -0.7
2,193,465 - Rv1940 0.81 -0.6
2,193,575 + -0.2
2,193,575 + -1.1
2,193,575 + +0.0
2,193,575 + -0.6
2,193,576 - +0.1
2,193,576 - +0.4
2,193,576 - -0.6

Or see this region's nucleotide sequence