Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1869c

Experiment: 7H9 with Levofloxacin 0.3 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1868 and Rv1869c are separated by 13 nucleotidesRv1869c and Rv1870c are separated by 99 nucleotidesRv1870c and Rv1871c are separated by 64 nucleotides Rv1868: Rv1868 - Conserved hypothetical protein, at 2,117,347 to 2,119,446 Rv1868 Rv1869c: Rv1869c - Probable reductase, at 2,119,460 to 2,120,695 Rv1869c Rv1870c: Rv1870c - Conserved hypothetical protein, at 2,120,795 to 2,121,430 Rv1870c Rv1871c: Rv1871c - Conserved protein, at 2,121,495 to 2,121,884 Rv1871c Position (kb) 2119 2120 2121Strain fitness (log2 ratio) -2 -1 0 1 2 3at 2118.463 kb on - strand, within Rv1868at 2118.664 kb on + strand, within Rv1868at 2118.784 kb on - strand, within Rv1868at 2118.827 kb on + strand, within Rv1868at 2119.286 kb on + strandat 2119.689 kb on + strand, within Rv1869cat 2119.690 kb on - strand, within Rv1869cat 2119.707 kb on + strand, within Rv1869cat 2119.726 kb on - strand, within Rv1869cat 2119.740 kb on + strand, within Rv1869cat 2119.740 kb on + strand, within Rv1869cat 2119.832 kb on + strand, within Rv1869cat 2119.869 kb on + strand, within Rv1869cat 2119.869 kb on + strand, within Rv1869cat 2119.869 kb on + strand, within Rv1869cat 2119.870 kb on - strand, within Rv1869cat 2120.081 kb on + strand, within Rv1869cat 2120.082 kb on - strand, within Rv1869cat 2120.082 kb on - strand, within Rv1869cat 2120.106 kb on - strand, within Rv1869cat 2120.339 kb on + strand, within Rv1869cat 2120.388 kb on + strand, within Rv1869cat 2120.696 kb on - strandat 2120.696 kb on - strandat 2120.696 kb on - strandat 2120.696 kb on - strandat 2120.796 kb on + strandat 2120.811 kb on - strandat 2120.920 kb on - strand, within Rv1870cat 2121.008 kb on - strand, within Rv1870cat 2121.008 kb on - strand, within Rv1870cat 2121.070 kb on - strand, within Rv1870cat 2121.127 kb on - strand, within Rv1870cat 2121.136 kb on - strand, within Rv1870cat 2121.136 kb on - strand, within Rv1870cat 2121.342 kb on + strand, within Rv1870cat 2121.342 kb on + strand, within Rv1870cat 2121.342 kb on + strand, within Rv1870cat 2121.343 kb on - strand, within Rv1870cat 2121.343 kb on - strand, within Rv1870cat 2121.361 kb on + strand, within Rv1870cat 2121.361 kb on + strand, within Rv1870cat 2121.362 kb on - strand, within Rv1870cat 2121.410 kb on - strandat 2121.439 kb on + strandat 2121.439 kb on + strandat 2121.469 kb on + strandat 2121.544 kb on - strand, within Rv1871cat 2121.568 kb on - strand, within Rv1871cat 2121.610 kb on + strand, within Rv1871cat 2121.611 kb on - strand, within Rv1871cat 2121.676 kb on + strand, within Rv1871cat 2121.676 kb on + strand, within Rv1871cat 2121.676 kb on + strand, within Rv1871cat 2121.676 kb on + strand, within Rv1871cat 2121.682 kb on + strand, within Rv1871cat 2121.682 kb on + strand, within Rv1871cat 2121.683 kb on - strand, within Rv1871c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Levofloxacin 0.3 ug/mL
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2,118,463 - Rv1868 0.53 -0.9
2,118,664 + Rv1868 0.63 +0.8
2,118,784 - Rv1868 0.68 -1.5
2,118,827 + Rv1868 0.70 -1.0
2,119,286 + -1.4
2,119,689 + Rv1869c 0.19 -0.1
2,119,690 - Rv1869c 0.19 +0.8
2,119,707 + Rv1869c 0.20 +0.3
2,119,726 - Rv1869c 0.22 -0.1
2,119,740 + Rv1869c 0.23 +0.2
2,119,740 + Rv1869c 0.23 -0.8
2,119,832 + Rv1869c 0.30 -0.9
2,119,869 + Rv1869c 0.33 -0.0
2,119,869 + Rv1869c 0.33 +2.4
2,119,869 + Rv1869c 0.33 -1.4
2,119,870 - Rv1869c 0.33 -0.8
2,120,081 + Rv1869c 0.50 +0.3
2,120,082 - Rv1869c 0.50 -0.0
2,120,082 - Rv1869c 0.50 +1.1
2,120,106 - Rv1869c 0.52 +1.8
2,120,339 + Rv1869c 0.71 -0.4
2,120,388 + Rv1869c 0.75 -1.4
2,120,696 - +0.2
2,120,696 - -0.3
2,120,696 - -0.5
2,120,696 - +2.4
2,120,796 + -0.2
2,120,811 - -0.8
2,120,920 - Rv1870c 0.20 +2.4
2,121,008 - Rv1870c 0.33 +2.4
2,121,008 - Rv1870c 0.33 -0.2
2,121,070 - Rv1870c 0.43 +1.3
2,121,127 - Rv1870c 0.52 -0.2
2,121,136 - Rv1870c 0.54 -1.6
2,121,136 - Rv1870c 0.54 +1.1
2,121,342 + Rv1870c 0.86 +0.1
2,121,342 + Rv1870c 0.86 -0.1
2,121,342 + Rv1870c 0.86 +0.1
2,121,343 - Rv1870c 0.86 -0.2
2,121,343 - Rv1870c 0.86 -0.7
2,121,361 + Rv1870c 0.89 -0.4
2,121,361 + Rv1870c 0.89 -0.1
2,121,362 - Rv1870c 0.89 -1.3
2,121,410 - +2.4
2,121,439 + -2.4
2,121,439 + -0.3
2,121,469 + +0.4
2,121,544 - Rv1871c 0.13 +0.3
2,121,568 - Rv1871c 0.19 -0.3
2,121,610 + Rv1871c 0.29 -0.5
2,121,611 - Rv1871c 0.30 -1.8
2,121,676 + Rv1871c 0.46 +1.4
2,121,676 + Rv1871c 0.46 -0.5
2,121,676 + Rv1871c 0.46 +0.6
2,121,676 + Rv1871c 0.46 +0.6
2,121,682 + Rv1871c 0.48 +0.6
2,121,682 + Rv1871c 0.48 +1.4
2,121,683 - Rv1871c 0.48 +3.0

Or see this region's nucleotide sequence