Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1601

Experiment: 7H9 with Levofloxacin 0.3 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1600 and Rv1601 overlap by 4 nucleotidesRv1601 and Rv1602 overlap by 4 nucleotidesRv1602 and Rv1603 are separated by 9 nucleotides Rv1600: Rv1600 - Probable histidinol-phosphate aminotransferase HisC1, at 1,800,896 to 1,802,038 Rv1600 Rv1601: Rv1601 - Probable imidazole glycerol-phosphate dehydratase HisB, at 1,802,035 to 1,802,667 Rv1601 Rv1602: Rv1602 - Probable amidotransferase HisH, at 1,802,664 to 1,803,284 Rv1602 Rv1603: Rv1603 - Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA, at 1,803,294 to 1,804,031 Rv1603 Position (kb) 1802 1803Strain fitness (log2 ratio) -1 0 1at 1803.307 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Levofloxacin 0.3 ug/mL
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1,803,307 + -1.2

Or see this region's nucleotide sequence