Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1500

Experiment: 7H9 with Levofloxacin 0.3 ug/mL

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

Per-strain Table

Position	Strand	Gene	LocusTag	Fraction	7H9 with Levofloxacin 0.3 ug/mL
1,689,988	+				+0.2
1,689,988	+				+0.6
1,689,988	+				-0.7
1,690,098	-				-2.0
1,690,166	+		Rv1498A	0.15	+0.8
1,690,167	-		Rv1498A	0.15	-1.6
1,690,167	-		Rv1498A	0.15	-0.3
1,690,221	+		Rv1498A	0.41	-2.3
1,690,221	+		Rv1498A	0.41	-0.4
1,690,330	+				+1.0
1,690,331	-				-0.2
1,690,368	-				-1.2
1,690,401	-				+0.6
1,690,401	-				-1.1
1,690,427	+				-2.3
1,690,428	-				+0.8
1,690,620	+		Rv1499	0.53	+1.9
1,690,620	+		Rv1499	0.53	-0.0
1,690,620	+		Rv1499	0.53	+1.8
1,690,689	+		Rv1499	0.71	+0.3
1,690,689	+		Rv1499	0.71	-0.4
1,690,689	+		Rv1499	0.71	-0.3
1,690,689	+		Rv1499	0.71	-0.5
1,690,690	-		Rv1499	0.71	-0.3
1,690,801	+				-0.1
1,690,801	+				-1.2
1,690,801	+				-1.5
1,690,801	+				+2.3
1,690,802	-				-0.7
1,690,802	-				-0.2
1,690,802	-				-1.1
1,690,802	-				+1.8
1,690,817	+				-0.4
1,690,817	+				-0.5
1,690,818	-				-1.5
1,690,822	+				+2.3
1,690,823	-				-0.6
1,690,873	+				-2.5
1,690,874	-				-1.0
1,690,874	-				-0.1
1,690,874	-				+1.5
1,690,877	+				-1.1
1,690,877	+				+0.0
1,690,877	+				+0.1
1,690,877	+				+0.3
1,690,878	-				-0.2
1,690,878	-				-0.2
1,690,878	-				-0.1
1,690,878	-				+1.3
1,690,878	-				-0.9
1,690,878	-				-0.2
1,690,892	+				-1.9
1,690,892	+				+0.8
1,690,892	+				-1.0
1,690,892	+				+2.3
1,690,893	-				+0.8
1,690,893	-				-1.2
1,690,893	-				+0.8
1,690,893	-				+0.8
1,690,893	-				+0.1
1,690,893	-				-0.2
1,690,893	-				+2.3
1,690,907	+				+0.0
1,690,907	+				-0.7
1,690,907	+				-0.2
1,691,199	+		Rv1500	0.34	-0.1
1,691,306	-		Rv1500	0.44	+0.6
1,691,306	-		Rv1500	0.44	+0.8
1,691,735	+		Rv1500	0.86	-0.7
1,692,109	+		Rv1501	0.27	+0.2
1,692,402	+		Rv1501	0.62	-0.3
1,692,406	+		Rv1501	0.63	-1.0
1,692,406	+		Rv1501	0.63	-2.2
1,692,469	-		Rv1501	0.70	+0.2
1,692,565	+		Rv1501	0.82	-1.4
1,692,565	+		Rv1501	0.82	-0.6
1,692,775	+				+0.0
1,692,776	-				+0.0
1,692,849	+				+1.2