Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1446c

Experiment: 7H9 with Levofloxacin 0.3 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1444c and Rv1445c are separated by 16 nucleotidesRv1445c and Rv1446c overlap by 4 nucleotidesRv1446c and Rv1447c are separated by 52 nucleotides Rv1444c: Rv1444c - Unknown protein, at 1,623,287 to 1,623,697 Rv1444c Rv1445c: Rv1445c - Probable 6-phosphogluconolactonase DevB (6PGL), at 1,623,714 to 1,624,457 Rv1445c Rv1446c: Rv1446c - Putative OXPP cycle protein OpcA, at 1,624,454 to 1,625,365 Rv1446c Rv1447c: Rv1447c - Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD), at 1,625,418 to 1,626,962 Rv1447c Position (kb) 1624 1625 1626Strain fitness (log2 ratio) -2 -1 0 1 2at 1623.481 kb on + strand, within Rv1444cat 1623.482 kb on - strand, within Rv1444cat 1624.237 kb on + strand, within Rv1445cat 1624.449 kb on - strandat 1624.449 kb on - strandat 1624.449 kb on - strandat 1624.830 kb on + strand, within Rv1446cat 1624.830 kb on + strand, within Rv1446cat 1624.830 kb on + strand, within Rv1446cat 1624.830 kb on + strand, within Rv1446cat 1625.420 kb on - strandat 1625.484 kb on - strandat 1625.484 kb on - strandat 1625.626 kb on + strand, within Rv1447cat 1625.882 kb on - strand, within Rv1447c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Levofloxacin 0.3 ug/mL
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1,623,481 + Rv1444c 0.47 -0.5
1,623,482 - Rv1444c 0.47 +0.3
1,624,237 + Rv1445c 0.70 +0.6
1,624,449 - -2.0
1,624,449 - -0.2
1,624,449 - -0.5
1,624,830 + Rv1446c 0.41 +2.3
1,624,830 + Rv1446c 0.41 -2.3
1,624,830 + Rv1446c 0.41 -1.2
1,624,830 + Rv1446c 0.41 +0.8
1,625,420 - -0.9
1,625,484 - -1.4
1,625,484 - +2.6
1,625,626 + Rv1447c 0.13 +0.8
1,625,882 - Rv1447c 0.30 +1.9

Or see this region's nucleotide sequence