Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1075c

Experiment: 7H9 with Levofloxacin 0.3 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1074c and Rv1075c are separated by 52 nucleotidesRv1075c and Rv1076 are separated by 396 nucleotides Rv1074c: Rv1074c - Probable beta-ketoacyl CoA thiolase FadA3, at 1,198,156 to 1,199,373 Rv1074c Rv1075c: Rv1075c - Conserved exported protein, at 1,199,426 to 1,200,370 Rv1075c Rv1076: Rv1076 - Possible lipase LipU, at 1,200,767 to 1,201,660 Rv1076 Position (kb) 1199 1200 1201Strain fitness (log2 ratio) -1 0 1 2 3 4at 1198.537 kb on + strand, within Rv1074cat 1198.537 kb on + strand, within Rv1074cat 1198.538 kb on - strand, within Rv1074cat 1198.866 kb on + strand, within Rv1074cat 1198.867 kb on - strand, within Rv1074cat 1198.868 kb on + strand, within Rv1074cat 1198.868 kb on + strand, within Rv1074cat 1198.868 kb on + strand, within Rv1074cat 1198.868 kb on + strand, within Rv1074cat 1198.868 kb on + strand, within Rv1074cat 1198.868 kb on + strand, within Rv1074cat 1198.868 kb on + strand, within Rv1074cat 1198.868 kb on + strand, within Rv1074cat 1198.868 kb on + strand, within Rv1074cat 1198.868 kb on + strand, within Rv1074cat 1198.869 kb on - strand, within Rv1074cat 1198.869 kb on - strand, within Rv1074cat 1198.869 kb on - strand, within Rv1074cat 1198.869 kb on - strand, within Rv1074cat 1198.869 kb on - strand, within Rv1074cat 1198.869 kb on - strand, within Rv1074cat 1198.869 kb on - strand, within Rv1074cat 1198.869 kb on - strand, within Rv1074cat 1198.869 kb on - strand, within Rv1074cat 1198.869 kb on - strand, within Rv1074cat 1198.869 kb on - strand, within Rv1074cat 1198.869 kb on - strand, within Rv1074cat 1199.420 kb on + strandat 1199.613 kb on + strand, within Rv1075cat 1199.687 kb on + strand, within Rv1075cat 1199.687 kb on + strand, within Rv1075cat 1199.688 kb on - strand, within Rv1075cat 1199.688 kb on - strand, within Rv1075cat 1199.688 kb on - strand, within Rv1075cat 1199.688 kb on - strand, within Rv1075cat 1199.868 kb on - strand, within Rv1075cat 1199.919 kb on - strand, within Rv1075cat 1199.919 kb on - strand, within Rv1075cat 1200.210 kb on + strand, within Rv1075cat 1200.210 kb on + strand, within Rv1075cat 1200.210 kb on + strand, within Rv1075cat 1200.211 kb on - strand, within Rv1075cat 1200.212 kb on + strand, within Rv1075cat 1200.212 kb on + strand, within Rv1075cat 1200.254 kb on + strand, within Rv1075cat 1200.306 kb on + strandat 1200.491 kb on - strandat 1200.608 kb on - strandat 1200.877 kb on - strand, within Rv1076at 1200.877 kb on - strand, within Rv1076at 1200.898 kb on + strand, within Rv1076at 1200.898 kb on + strand, within Rv1076at 1200.899 kb on - strand, within Rv1076at 1200.899 kb on - strand, within Rv1076at 1200.899 kb on - strand, within Rv1076at 1200.899 kb on - strand, within Rv1076at 1200.899 kb on - strand, within Rv1076at 1201.152 kb on - strand, within Rv1076

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Levofloxacin 0.3 ug/mL
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1,198,537 + Rv1074c 0.31 -1.2
1,198,537 + Rv1074c 0.31 -0.5
1,198,538 - Rv1074c 0.31 -0.0
1,198,866 + Rv1074c 0.58 -0.7
1,198,867 - Rv1074c 0.58 -0.7
1,198,868 + Rv1074c 0.58 -0.7
1,198,868 + Rv1074c 0.58 -1.2
1,198,868 + Rv1074c 0.58 -0.2
1,198,868 + Rv1074c 0.58 -0.2
1,198,868 + Rv1074c 0.58 -0.3
1,198,868 + Rv1074c 0.58 -0.5
1,198,868 + Rv1074c 0.58 +1.2
1,198,868 + Rv1074c 0.58 +3.2
1,198,868 + Rv1074c 0.58 -0.8
1,198,868 + Rv1074c 0.58 -0.3
1,198,869 - Rv1074c 0.59 -0.0
1,198,869 - Rv1074c 0.59 +1.0
1,198,869 - Rv1074c 0.59 +0.5
1,198,869 - Rv1074c 0.59 +0.6
1,198,869 - Rv1074c 0.59 +1.3
1,198,869 - Rv1074c 0.59 +0.3
1,198,869 - Rv1074c 0.59 +1.0
1,198,869 - Rv1074c 0.59 +0.0
1,198,869 - Rv1074c 0.59 +0.4
1,198,869 - Rv1074c 0.59 -0.1
1,198,869 - Rv1074c 0.59 +0.8
1,198,869 - Rv1074c 0.59 -1.1
1,199,420 + -1.0
1,199,613 + Rv1075c 0.20 -0.2
1,199,687 + Rv1075c 0.28 +0.9
1,199,687 + Rv1075c 0.28 -0.0
1,199,688 - Rv1075c 0.28 -0.0
1,199,688 - Rv1075c 0.28 +0.2
1,199,688 - Rv1075c 0.28 +0.9
1,199,688 - Rv1075c 0.28 -0.1
1,199,868 - Rv1075c 0.47 +0.5
1,199,919 - Rv1075c 0.52 +0.4
1,199,919 - Rv1075c 0.52 +0.0
1,200,210 + Rv1075c 0.83 -1.2
1,200,210 + Rv1075c 0.83 -0.0
1,200,210 + Rv1075c 0.83 -1.0
1,200,211 - Rv1075c 0.83 +0.3
1,200,212 + Rv1075c 0.83 +0.7
1,200,212 + Rv1075c 0.83 +0.9
1,200,254 + Rv1075c 0.88 +0.2
1,200,306 + +0.6
1,200,491 - +0.1
1,200,608 - -1.2
1,200,877 - Rv1076 0.12 -0.7
1,200,877 - Rv1076 0.12 +1.1
1,200,898 + Rv1076 0.15 +2.5
1,200,898 + Rv1076 0.15 +0.2
1,200,899 - Rv1076 0.15 +0.2
1,200,899 - Rv1076 0.15 +3.9
1,200,899 - Rv1076 0.15 -0.3
1,200,899 - Rv1076 0.15 +2.3
1,200,899 - Rv1076 0.15 +1.9
1,201,152 - Rv1076 0.43 +0.7

Or see this region's nucleotide sequence