Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0781

Experiment: 7H9 with Levofloxacin 0.3 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0779c and Rv0780 are separated by 50 nucleotidesRv0780 and Rv0781 overlap by 4 nucleotidesRv0781 and Rv0782 overlap by 212 nucleotides Rv0779c: Rv0779c - Possible conserved transmembrane protein, at 872,672 to 873,292 Rv0779c Rv0780: Rv0780 - Phosphoribosylaminoimidazole-succinocarboxamide synthase PurC (SAICAR synthetase), at 873,343 to 874,236 Rv0780 Rv0781: Rv0781 - Probable protease II PtrBa [first part] (oligopeptidase B), at 874,233 to 874,943 Rv0781 Rv0782: Rv0782 - Probable protease II PtrBb [second part] (oligopeptidase B), at 874,732 to 876,390 Rv0782 Position (kb) 874 875Strain fitness (log2 ratio) -2 -1 0 1at 873.301 kb on + strandat 873.302 kb on - strandat 874.540 kb on + strand, within Rv0781at 874.713 kb on + strand, within Rv0781at 875.285 kb on - strand, within Rv0782at 875.496 kb on + strand, within Rv0782at 875.546 kb on - strand, within Rv0782at 875.860 kb on - strand, within Rv0782

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Levofloxacin 0.3 ug/mL
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873,301 + -0.1
873,302 - +0.2
874,540 + Rv0781 0.43 -0.7
874,713 + Rv0781 0.68 -1.1
875,285 - Rv0782 0.33 -0.5
875,496 + Rv0782 0.46 +0.3
875,546 - Rv0782 0.49 -2.1
875,860 - Rv0782 0.68 -0.5

Or see this region's nucleotide sequence