Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0396

Experiment: 7H9 with Levofloxacin 0.3 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0394c and Rv0395 are separated by 98 nucleotidesRv0395 and Rv0396 are separated by 5 nucleotidesRv0396 and Rv0397 are separated by 73 nucleotidesRv0397 and Rv0397A are separated by 209 nucleotidesRv0397A and Rv0398c are separated by 36 nucleotides Rv0394c: Rv0394c - Possible secreted protein, at 474,122 to 474,841 Rv0394c Rv0395: Rv0395 - Hypothetical protein, at 474,940 to 475,344 Rv0395 Rv0396: Rv0396 - Hypothetical protein, at 475,350 to 475,742 Rv0396 Rv0397: Rv0397 - Conserved 13E12 repeat family protein, at 475,816 to 476,184 Rv0397 Rv0397A: Rv0397A - Conserved protein, at 476,394 to 476,642 Rv0397A Rv0398c: Rv0398c - Possible secreted protein, at 476,679 to 477,320 Rv0398c Position (kb) 475 476Strain fitness (log2 ratio) -2 -1 0 1 2at 474.386 kb on - strand, within Rv0394cat 474.476 kb on - strand, within Rv0394cat 474.593 kb on - strand, within Rv0394cat 474.698 kb on + strand, within Rv0394cat 474.841 kb on + strandat 474.854 kb on - strandat 474.854 kb on - strandat 474.854 kb on - strandat 474.854 kb on - strandat 475.140 kb on + strand, within Rv0395at 475.227 kb on + strand, within Rv0395at 475.260 kb on - strand, within Rv0395at 475.326 kb on - strandat 475.326 kb on - strandat 475.342 kb on + strandat 475.343 kb on - strandat 475.343 kb on - strandat 475.369 kb on + strandat 475.438 kb on - strand, within Rv0396at 475.438 kb on - strand, within Rv0396at 475.898 kb on - strand, within Rv0397at 475.898 kb on - strand, within Rv0397at 475.898 kb on - strand, within Rv0397at 476.183 kb on - strandat 476.314 kb on + strandat 476.315 kb on - strandat 476.345 kb on + strandat 476.426 kb on - strand, within Rv0397Aat 476.545 kb on + strand, within Rv0397Aat 476.546 kb on - strand, within Rv0397Aat 476.547 kb on + strand, within Rv0397Aat 476.547 kb on + strand, within Rv0397Aat 476.681 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Levofloxacin 0.3 ug/mL
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474,386 - Rv0394c 0.37 +0.7
474,476 - Rv0394c 0.49 -1.3
474,593 - Rv0394c 0.65 -0.4
474,698 + Rv0394c 0.80 -1.3
474,841 + -0.5
474,854 - -0.5
474,854 - -0.7
474,854 - +0.5
474,854 - -0.8
475,140 + Rv0395 0.49 +0.1
475,227 + Rv0395 0.71 -0.6
475,260 - Rv0395 0.79 -1.8
475,326 - +0.0
475,326 - -0.2
475,342 + -0.4
475,343 - -0.4
475,343 - +0.9
475,369 + +0.4
475,438 - Rv0396 0.22 -0.3
475,438 - Rv0396 0.22 -1.6
475,898 - Rv0397 0.22 -0.5
475,898 - Rv0397 0.22 -0.9
475,898 - Rv0397 0.22 +0.1
476,183 - +2.0
476,314 + +0.1
476,315 - -1.2
476,345 + +0.2
476,426 - Rv0397A 0.13 -0.5
476,545 + Rv0397A 0.61 -0.9
476,546 - Rv0397A 0.61 -0.2
476,547 + Rv0397A 0.61 -1.3
476,547 + Rv0397A 0.61 +2.3
476,681 - +0.6

Or see this region's nucleotide sequence