Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0939

Experiment: 7H9 with Moxifloxacin 0.121 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0938 and Rv0939 overlap by 4 nucleotidesRv0939 and Rv0940c are separated by 246 nucleotides Rv0938: Rv0938 - ATP dependent DNA ligase LigD (ATP dependent polydeoxyribonucleotide synthase) (thermostable DNA ligase) (ATP dependent polynucleotide ligase) (sealase) (DNA repair enzyme) (DNA joinase), at 1,046,136 to 1,048,415 Rv0938 Rv0939: Rv0939 - Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase, at 1,048,412 to 1,050,346 Rv0939 Rv0940c: Rv0940c - Possible oxidoreductase, at 1,050,593 to 1,051,459 Rv0940c Position (kb) 1048 1049 1050 1051Strain fitness (log2 ratio) -1 0 1 2at 1048.005 kb on + strand, within Rv0938at 1048.255 kb on + strandat 1048.290 kb on + strandat 1048.291 kb on - strandat 1048.479 kb on - strandat 1049.136 kb on - strand, within Rv0939at 1049.525 kb on - strand, within Rv0939at 1050.248 kb on + strandat 1050.248 kb on + strandat 1051.318 kb on - strand, within Rv0940c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Moxifloxacin 0.121 ug/mL
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1,048,005 + Rv0938 0.82 +0.4
1,048,255 + -1.2
1,048,290 + -1.2
1,048,291 - -0.5
1,048,479 - -1.2
1,049,136 - Rv0939 0.37 +0.2
1,049,525 - Rv0939 0.58 +1.9
1,050,248 + +0.8
1,050,248 + +0.2
1,051,318 - Rv0940c 0.84 +0.1

Or see this region's nucleotide sequence