Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0069c

Experiment: 7H9 with Moxifloxacin 0.121 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0068 and Rv0069c are separated by 24 nucleotidesRv0069c and Rv0070c overlap by 4 nucleotides Rv0068: Rv0068 - Probable oxidoreductase, at 75,301 to 76,212 Rv0068 Rv0069c: Rv0069c - Probable L-serine dehydratase SdaA (L-serine deaminase) (SDH) (L-SD), at 76,237 to 77,622 Rv0069c Rv0070c: Rv0070c - Serine hydroxymethyltransferase GlyA2 (serine methylase 2) (SHMT 2), at 77,619 to 78,896 Rv0070c Position (kb) 76 77 78Strain fitness (log2 ratio) -1 0 1 2at 75.286 kb on + strandat 75.287 kb on - strandat 75.613 kb on + strand, within Rv0068at 75.613 kb on + strand, within Rv0068at 75.613 kb on + strand, within Rv0068at 75.614 kb on - strand, within Rv0068at 75.614 kb on - strand, within Rv0068at 75.614 kb on - strand, within Rv0068at 75.614 kb on - strand, within Rv0068at 75.614 kb on - strand, within Rv0068at 75.616 kb on - strand, within Rv0068at 76.070 kb on - strand, within Rv0068at 76.298 kb on + strandat 77.006 kb on - strand, within Rv0069cat 77.530 kb on + strandat 78.568 kb on - strand, within Rv0070c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Moxifloxacin 0.121 ug/mL
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75,286 + -0.7
75,287 - -0.8
75,613 + Rv0068 0.34 +2.0
75,613 + Rv0068 0.34 -0.3
75,613 + Rv0068 0.34 -0.1
75,614 - Rv0068 0.34 +0.3
75,614 - Rv0068 0.34 +2.6
75,614 - Rv0068 0.34 -0.7
75,614 - Rv0068 0.34 +0.1
75,614 - Rv0068 0.34 -0.3
75,616 - Rv0068 0.35 +0.3
76,070 - Rv0068 0.84 -0.6
76,298 + -0.5
77,006 - Rv0069c 0.55 +0.1
77,530 + -0.3
78,568 - Rv0070c 0.74 +0.0

Or see this region's nucleotide sequence