Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3651

Experiment: 7H9 with Moxifloxacin 0.121 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3649 and Rv3650 are separated by 136 nucleotidesRv3650 and Rv3651 are separated by 323 nucleotidesRv3651 and Rv3652 are separated by 753 nucleotides Rv3649: Rv3649 - Probable helicase, at 4,088,781 to 4,091,096 Rv3649 Rv3650: Rv3650 - PE family protein PE33, at 4,091,233 to 4,091,517 Rv3650 Rv3651: Rv3651 - Conserved hypothetical protein, at 4,091,841 to 4,092,878 Rv3651 Rv3652: Rv3652 - PE-PGRS family-related protein PE_PGRS60, at 4,093,632 to 4,093,946 Rv3652 Position (kb) 4091 4092 4093Strain fitness (log2 ratio) -1 0 1at 4091.189 kb on - strandat 4091.417 kb on - strand, within Rv3650at 4091.571 kb on + strandat 4091.572 kb on - strandat 4091.605 kb on + strandat 4091.606 kb on - strandat 4092.061 kb on + strand, within Rv3651at 4092.061 kb on + strand, within Rv3651at 4092.606 kb on + strand, within Rv3651at 4093.553 kb on + strandat 4093.638 kb on + strandat 4093.638 kb on + strandat 4093.638 kb on + strandat 4093.792 kb on - strand, within Rv3652at 4093.814 kb on + strand, within Rv3652at 4093.814 kb on + strand, within Rv3652at 4093.815 kb on - strand, within Rv3652

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Moxifloxacin 0.121 ug/mL
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4,091,189 - +0.4
4,091,417 - Rv3650 0.65 -0.7
4,091,571 + -0.4
4,091,572 - -0.1
4,091,605 + +0.4
4,091,606 - +1.0
4,092,061 + Rv3651 0.21 -0.9
4,092,061 + Rv3651 0.21 -0.9
4,092,606 + Rv3651 0.74 -0.1
4,093,553 + +0.2
4,093,638 + -0.0
4,093,638 + -0.1
4,093,638 + -0.8
4,093,792 - Rv3652 0.51 -0.7
4,093,814 + Rv3652 0.58 -0.0
4,093,814 + Rv3652 0.58 -0.5
4,093,815 - Rv3652 0.58 -1.1

Or see this region's nucleotide sequence