Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3370c

Experiment: 7H9 with Moxifloxacin 0.121 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3368c and Rv3369 overlap by 2 nucleotidesRv3369 and Rv3370c are separated by 88 nucleotidesRv3370c and Rv3371 are separated by 191 nucleotides Rv3368c: Rv3368c - Possible oxidoreductase, at 3,780,335 to 3,780,979 Rv3368c Rv3369: Rv3369 - Conserved protein, at 3,780,978 to 3,781,412 Rv3369 Rv3370c: Rv3370c - Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase), at 3,781,501 to 3,784,740 Rv3370c Rv3371: Rv3371 - Possible triacylglycerol synthase (diacylglycerol acyltransferase), at 3,784,932 to 3,786,272 Rv3371 Position (kb) 3781 3782 3783 3784 3785Strain fitness (log2 ratio) -2 -1 0 1 2 3at 3780.754 kb on - strand, within Rv3368cat 3781.113 kb on + strand, within Rv3369at 3781.114 kb on - strand, within Rv3369at 3781.141 kb on - strand, within Rv3369at 3781.296 kb on + strand, within Rv3369at 3781.308 kb on + strand, within Rv3369at 3781.309 kb on - strand, within Rv3369at 3781.309 kb on - strand, within Rv3369at 3781.356 kb on + strand, within Rv3369at 3782.457 kb on - strand, within Rv3370cat 3782.510 kb on + strand, within Rv3370cat 3782.730 kb on - strand, within Rv3370cat 3782.795 kb on + strand, within Rv3370cat 3782.796 kb on - strand, within Rv3370cat 3782.891 kb on + strand, within Rv3370cat 3783.363 kb on - strand, within Rv3370cat 3783.371 kb on + strand, within Rv3370cat 3783.378 kb on - strand, within Rv3370cat 3783.512 kb on + strand, within Rv3370cat 3783.512 kb on + strand, within Rv3370cat 3784.604 kb on + strandat 3784.895 kb on + strandat 3784.895 kb on + strandat 3784.896 kb on - strandat 3784.896 kb on - strandat 3784.896 kb on - strandat 3785.096 kb on + strand, within Rv3371

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Moxifloxacin 0.121 ug/mL
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3,780,754 - Rv3368c 0.65 +0.7
3,781,113 + Rv3369 0.31 -0.3
3,781,114 - Rv3369 0.31 +0.8
3,781,141 - Rv3369 0.37 +0.6
3,781,296 + Rv3369 0.73 -0.6
3,781,308 + Rv3369 0.76 +0.2
3,781,309 - Rv3369 0.76 -1.3
3,781,309 - Rv3369 0.76 +0.5
3,781,356 + Rv3369 0.87 -1.6
3,782,457 - Rv3370c 0.30 -1.2
3,782,510 + Rv3370c 0.31 -0.2
3,782,730 - Rv3370c 0.38 +2.2
3,782,795 + Rv3370c 0.40 -0.0
3,782,796 - Rv3370c 0.40 +0.2
3,782,891 + Rv3370c 0.43 +0.0
3,783,363 - Rv3370c 0.57 -0.3
3,783,371 + Rv3370c 0.58 -0.4
3,783,378 - Rv3370c 0.58 -0.3
3,783,512 + Rv3370c 0.62 -0.4
3,783,512 + Rv3370c 0.62 -1.5
3,784,604 + +3.6
3,784,895 + -0.4
3,784,895 + +0.3
3,784,896 - -0.1
3,784,896 - -2.1
3,784,896 - -0.5
3,785,096 + Rv3371 0.12 +2.5

Or see this region's nucleotide sequence