Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2686c

Experiment: 7H9 with Moxifloxacin 0.121 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2685 and Rv2686c are separated by 10 nucleotidesRv2686c and Rv2687c overlap by 4 nucleotidesRv2687c and Rv2688c overlap by 4 nucleotides Rv2685: Rv2685 - Probable arsenic-transport integral membrane protein ArsB1, at 3,001,983 to 3,003,269 Rv2685 Rv2686c: Rv2686c - Antibiotic-transport integral membrane leucine and alanine and valine rich protein ABC transporter, at 3,003,280 to 3,004,038 Rv2686c Rv2687c: Rv2687c - Antibiotic-transport integral membrane leucine and valine rich protein ABC transporter, at 3,004,035 to 3,004,748 Rv2687c Rv2688c: Rv2688c - Antibiotic-transport ATP-binding protein ABC transporter, at 3,004,745 to 3,005,650 Rv2688c Position (kb) 3003 3004 3005Strain fitness (log2 ratio) -2 -1 0 1at 3002.359 kb on + strand, within Rv2685at 3002.360 kb on - strand, within Rv2685at 3002.923 kb on + strand, within Rv2685at 3003.268 kb on - strandat 3003.336 kb on - strandat 3003.356 kb on + strand, within Rv2686cat 3003.656 kb on + strand, within Rv2686cat 3003.657 kb on - strand, within Rv2686cat 3004.064 kb on - strandat 3004.213 kb on + strand, within Rv2687cat 3004.214 kb on - strand, within Rv2687cat 3004.604 kb on - strand, within Rv2687cat 3004.662 kb on - strand, within Rv2687cat 3004.707 kb on + strandat 3004.805 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Moxifloxacin 0.121 ug/mL
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3,002,359 + Rv2685 0.29 +0.7
3,002,360 - Rv2685 0.29 +1.3
3,002,923 + Rv2685 0.73 -0.1
3,003,268 - -0.2
3,003,336 - -0.8
3,003,356 + Rv2686c 0.10 -0.2
3,003,656 + Rv2686c 0.50 -1.6
3,003,657 - Rv2686c 0.50 -1.4
3,004,064 - -1.2
3,004,213 + Rv2687c 0.25 -0.7
3,004,214 - Rv2687c 0.25 -2.3
3,004,604 - Rv2687c 0.80 +0.3
3,004,662 - Rv2687c 0.88 +0.8
3,004,707 + -0.4
3,004,805 - -0.3

Or see this region's nucleotide sequence